Achievement of Dietetic and Exercise Therapy Evaluated by Self-assessment Score Significantly Improved Endothelial Dysfunction in Patients With Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Endothelial function assessed by RH-PAT
研究概览
简要总结
Life-style intervention with dietetic and exercise therapy is an important fundamental approach to patients with metabolic syndrome (MetSyd) which may cause endothelial dysfunction leading to cardiovascular events. We investigated whether the life-style modification by dietetic and exercise instruction could improve endothelial dysfunction assessed by a new non-invasive and automatic device; digital reactive hyperemia peripheral arterial tonometry (RH-PAT).
详细描述
Outline of methods RH-PAT was measured in high-risk patients under 70 years old. The MetSyd was defined according to guidelines of the National Cholesterol Education Program Third Adult Treatment Panel (NCEP - ATP III). We instructed all MetSyd patients about the dietetic and exercise therapy according to the Japan Atherosclerosis Society Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases. we conducted a questionnaire survey of the self-assessment for dietetic and exercise instruction program, respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Under 70 years old and preserved left ventricular systolic function (left ventricular ejection fraction ≥ 50%)
排除标准
- •Severe valvular heart disease
- •Atrial septal defect
- •Myocarditis
- •Cardiomyopathy
- •Active inflammatory diseases
- •Pulmonary hypertension
- •Chronic kidney disease on hemodialysis
- •Advanced hepatic disease
- •Schizophrenia; AND
- •Cerebrovascular disease and residual hemiplegia.
研究组 & 干预措施
Lifestyle instruction
干预措施: Lifestyle instruction (Other)
结局指标
主要结局
Endothelial function assessed by RH-PAT
时间窗: About 1 year later
次要结局
- Metabolic status including waist circumference(About 1 year later)
研究者
Seigo Sugiyama
MD, PhD
Kumamoto University