Cognitive-motor Training on Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- National Yang Ming Chiao Tung University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Gait variability
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.
Investigators
Yea-Ru Yang
Professor
National Yang Ming Chiao Tung University
Eligibility Criteria
Inclusion Criteria
- •Diagnoses of idiopathic Parkinson disease
- •Stable dopaminergic medicine ≥ 2 weeks
- •Able to walk 10 meters without aid
- •Mini-Mental Status Examination ≥ 24 points
- •No uncorrected visual or auditory disorders
- •Education at least junior high school
- •No other disease may affect balance
Exclusion Criteria
- •Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
- •History of brain surgery (e.g. deep brain stimulation)
Outcomes
Primary Outcomes
Gait variability
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%
Gait speed
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure gait speed
Step length
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure step length
Step width
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure step width
Single support time
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure single support time
Double support time
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure double support time
Frontal Assessment Battery
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
The score ranged from 0 to 18. Higher scores show better executive function.
Stroop color and word test
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Record numbers of corrected color words which the subject responds within 45 sec.
Digit span test
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
Event-related potential - N2
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Event-related potential - P300
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Go/Nogo test
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Behavioral test during measuring electroencephalography.
Trail making test
Time Frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
Secondary Outcomes
- Mini-Balance Evaluation Systems Test(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
- Montreal Cognitive Assessment(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
- Timed up and go test(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)
- Parkinson Disease Questionnaire(Before and after 8 weeks of intervention, as well as 4 weeks after intervention)