Development of enzyme-based products for oral care

Not Applicable

Conditions: K05
K02
Gingivitis and periodontal diseases
Dental caries

Registration Number: DRKS00009823

Lead Sponsor: Klinik für Präventivzahnmedizin, Parodontologie und Kariologie (PPK)Zentrum für ZahnmedizinUniversität Zürich

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 20

Inclusion Criteria

10 female + 10 male subjects (stratified study), in the age of at least 18 years
- either full dentition or partial missing (at least 3 adjacent posterior teeth with no more than 2 approximate and/or 2 buccal restorations on both maxilla sides without buccal dental veneer)
- caries-free denture
- Gingiva free of inflammation
- interdental brushes should be applicable
- signed information sheet
- subjects should be able to perform the study plan

Exclusion Criteria

- artificial dentition
- pregnant and lactating women
- patients participating in any other clinical trial within the last 3 months prior to enrollment
- lack of compliance (adherence)
- patients taking antibiotics during study
- alcoholic-, drug- or medicaments abuse
- patients with known sensibilities against ingredients of the used dentifrices
- strong smoker (more than 10 cigarettes per day)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
After the preparation phase , the testing phase can be started with the test toothpastes (only high responder) . Here, baseline and post-treatment measurements will be compared of the amount of bacteria, degree of inflammation, and the amount of plaque in dependence of the respective test toothpastes. Baseline measurements are taken on day 0, post-treatment measurements in each cycle (4 in total) on day 4. In each case, a clinical examination is carried out .<br>

Secondary Outcome Measures

Name	Time	Method
The cleaning effect of the differently shaped interdental brushes will be examined in the preparation phase . In addition, so-called high responders are included in the study . Clinical examinations (measurements) will be performed on day 0 and day 4 (bacteria load, degree of inflammation of the gums , probing depth) .<br><br>