Effects of Chewing Gum Against Postoperative Ileus

Not Applicable

• Conditions: Pancreas Neoplasm
• Interventions: Other: gum

• Registration Number: NCT04768660
• Lead Sponsor: Assiut University

Brief Summary

The purpose of this study is to determine whether the use of chewing gum effects postoperative ileus after pancreaticoduodenectomy

Detailed Description

Postoperative ileus is common after surgery. One non-pharmacological intervention that has shown promising results in reducing the duration of postoperative ileus is chewing gum after surgery. However, this has not been investigated in upper gastrointestinal surgery such as pancreatic surgery. Hence the aim of this study was to investigate the effects of chewing gum treatment on patients undergoing pancreaticoduodenectomy due to pancreatic or periampullary cancer.

This study was conducted as a phase-III trial. Patients diagnosed with pancreatic tumours scheduled for pancreaticoduodenectomy were included. The treatment group received chewing gum postoperatively and standard care. Controls received glucose solution and standard care.

Study Timeline

• Status Verified: 2020-09
• Study Start: 2021-02-14
• Study First Submitted: 2021-02-21
• Study First Submitted QC: 2021-02-21
• Last Update Submitted: 2021-02-21
• Study First Posted: 2021-02-24
• Last Update Posted: 2021-02-24
• Primary Completion: 2023-03
• Study Completion: 2023-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Pancreatic or periampullary cancer and scheduled to undergo pancreaticoduodenectomy.

Exclusion Criteria

• 2. Ongoing treatment for mental disease 3. Diagnosed neurological injuries or diseases affecting the ability to swallow or gastric function 4. Ongoing abuse of alcohol or other drugs 5. Previously known allergies to the content of chewing gum 6. Additional surgery after primary surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
normal	gum	people will not use chewing gums after whipple operation

Primary Outcome Measures

Name	Time	Method
Length of hospital stay	(with in the first 21 days) ]	Time Frame: From day of surgery until discharge from surgical ward
First flatus after surgery	(with in the first 21 days)	From day of surgery until first postoperative flatus