Influence of dietary omega-6/omega-3 fatty acid ratio on vascular health in patients treated with statins

Not Applicable

Recruiting

• Conditions: Cardiovascular disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12609000464268
• Lead Sponsor: Baker IDI Heart & Diabetes Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-06-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Treated with statins

Exclusion Criteria

Prior history of clinically relevant atheroma, current smokers, diabetes, obesity.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vascular stiffness (compliance & distensibility). <br>Assessment of brachial artery elasticity (compliance & distensibility) using high-resolution ultrasound.<br>Assessment of systemic compliance/stiffness using pulse wave analysis derived from applanation tonometry.[All measures are assessed on day 0 and day 28 (after 4 weeks dietary intervention). The trial has a randomised crossover design, with an 8-week washout phase. The measures are repeated for the second diet.];CD11b expression on monocytes is a measure of inflammation. CD11b expression is assessed via flow cytometry.[All measures are assessed on day 0 and day 28 (after 4 weeks dietary intervention). The trial has a randomised crossover design, with an 8-week washout phase. The measures are repeated for the second diet.]

Secondary Outcome Measures

Name	Time	Method
Heart rate variability. Measured using a 5-minute 12-lead electrocardiogram (ECG).[All measures are assessed on day 0 and day 28 (after 4 weeks dietary intervention). The trial has a randomised crossover design, with an 8-week washout phase. The measures are repeated for the second diet.]