Effect of Different Exercise Training Methods on the Radiographic and Inflammatory Biomarkers (CRP, TNF-α, IL-2, IL-4, IL-6) in Chronic Low Back Pain: A Randomized Control Study.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Low Back Pain
- Sponsor
- Prince Sattam Bin Abdulaziz University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Pain Intensity
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
OBJECTIVE: To find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects in chronic low back pain (LBP) patients.
Detailed Description
OBJECTIVE: To find and compare the effects of isokinetic training and virtual reality training on pain intensity, trunk muscle strength, radiographical (muscle cross-sectional area and muscle thickness), and biochemical effects in chronic low back pain (LBP) patients. METHODS: Randomized, double-blinded controlled study was conducted on 60 LBP patients and they were divided into isokinetic training (IKT; n=20), virtual reality training (VRT; n=20), and a control group (n=20). The VRT group received virtual training for core muscles of the trunk, the IKT group received training for trunk muscles through an Isokinetic dynamometer and the control group received conventional trunk balance exercises. Pain intensity (visual analog scale -VAS), trunk muscle strength, radiographical (muscle cross-sectional area through Magnetic resonance imaging - MRI \& muscle thickness through Ultrasound - US), and biochemical (CRP, TNF-α, IL-2, IL-4, IL-6) variables were measured at baseline and after 4 weeks (short term effect) of training.
Investigators
Gopal Nambi
Associate Professor
Prince Sattam Bin Abdulaziz University
Eligibility Criteria
Inclusion Criteria
- •University male football players
- •Age group of 18 - 25 years
- •chronic (≥3 months) LBP,
- •4 to 8 pain intensity in visual analog scale (VAS).
Exclusion Criteria
- •Participants with severe musculoskeletal, neural, somatic, and psychiatric conditions,
- •Waiting for spine surgery,
- •Having alcohol or drug abuse,
- •Involved in other weight and balance training programs.
- •Participants with other soft tissue injuries, fractures in the lower limbs and pelvic bone, deformities.
Outcomes
Primary Outcomes
Pain Intensity
Time Frame: After 4 weeks
The pain intensity was measured by visual analog scale (VAS) which consist of a 10 cm horizontal line representing one end with "no pain at all" and the other end with "as bad as possible it could be." Each subject was asked to enter in the line as per his pain perception at rest and the score was measured by the distance on the line. The reliability and validity of VAS in application of musculoskeletal conditions was good.
Trunk flexor & extensor muscle strength
Time Frame: After 4 weeks
The trunk flexor and extensor muscles' peak torque was measured by using isokinetic dynamometer. The participant was positioned in standing position and wrapped the lower extremities with Velcro straps to prevent trick movements. Three measurements were taken at 900 per second for trunk flexors and extensors and the average value was considered for data analysis. The reliability and validity of this method of application in low back pain condition was good.
Secondary Outcomes
- Para spinal CSA(Baseline and after 4 weeks)
- Muscle thickness(Baseline and after 4 weeks)
- Inflammatory Biomarker(Baseline and after 4 weeks)