Healthy Aging Longitudinal Study in Taiwan (HALST)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 5,664
- 主要终点
- Independence in daily life assessed by Lawton-Brody Instrumental Activities of Daily Living (IADL) scale
研究概览
简要总结
The general aim of this study is to establish a longitudinal cohort of older persons in order to examine the physiological, environmental and genetic risk factors for physical disability, frailty, cardiovascular disease, and neuropsychiatric disorders in older persons and to examine the benefit of healthy lifestyles. The findings from this study will provide information necessary for the development of effective health policy for aging people.
详细描述
In the proposed research, investigators plan to conduct a longitudinal study on a cohort of 5,000+ men and women ages 55 years or older to address issues related to healthy aging. The study population consists community-based middle to old aged men and women in the catchment area of 7 hospitals (2 in the north, 2 in the middle, 2 in the south and 1 in the east, about half urban half rural). In this proposed study, investigators will recruit the subjects in the catchment area of the above 7 hospitals and expand data collection to include more interviewer-administered data, physical examinations and blood and urine specimens.
In addition, the cohort will be followed annually for mortality and morbidity and will be re-examined every five years.
For this newly proposed study, in order to systematically address issues related to healthy aging, specific aims are grouped into five inter-related areas of emphasis (five component projects). The five component projects are:
A. Factors that may influence physical functioning and its changes in older persons.
B. The benefit of healthy lifestyles on cardiovascular disease risk profile, quality of life and physical functioning in older persons.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 104 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ages 55 years or older
排除标准
- •high transmitted disease (such as scabies, open pulmonary tuberculosis)
- •severe illness (such as cancer under treatment)
- •diagnosed dementia
- •severe illness and being bed-ridden, unable to move
- •severe mental disorder, cannot be communicated with（MMSE<16）
- •dumbness or hearing impairment, unable to complete the interview
- •unsighted completely, unable to complete the interview and test
- •< 55 years of age
- •Other conditions, such as living in a long-term care facility or being hospitalized
结局指标
主要结局
Independence in daily life assessed by Lawton-Brody Instrumental Activities of Daily Living (IADL) scale
时间窗: 20 years
IADL scale is used to measure a participant's ability to adapt to the environment and consists of 8 tasks: shopping, housekeeping, money management, food preparation, laundry, transportation, use of the telephone, and medications. The total score is from 0 (worst) to 8 (best).
Dementia incidence by linking the National Health Insurance Research Database in Taiwan
时间窗: 20 years
Overall cancer incidence by linking the National Health Insurance Research Database in Taiwan
时间窗: 20 years
Independence in daily life assessed by Barthel Index
时间窗: 20 years
The Barthel Index will be adapted to assess the ability to cope with 10 items of daily activities. These tasks include feeding, moving from wheelchair to bed, personal toilet, getting on and off the toilet, bathing, walking on a level surface, ascending and descending stairs, dressing, controlling bowel, and controlling bladder. The total score ranges from 0 to 100, with 100 representing full independence in doing daily activities.
Cardiovascular disease incidence by linking the National Health Insurance Research Database in Taiwan
时间窗: 20 years
All cause mortality
时间窗: 20 years
Declined rate of physical performance assessed by peak flow test
时间窗: 20 years
The peak flow test, is a measure of lung function, the participant is asked to take a deep breath and blow as fast and hard as possible into the meter at a standing or sitting position. The maximum value in liter per minute of three to five trials of forced expiration is chosen as the peak flow.
Declined rate of physical performance assessed by grip strength
时间窗: 20 years
The participant is instructed to use the dominant hand to grip the dynamometer as hard as possible three times. The maximum value in kilograms of three trials is recorded as maximal grip strength.
Declined rate of physical performance assessed by Summary Physical Performance Battery (SPPB)
时间窗: 20 years
The SPPB, is a measure of lower extremity function and represents the participant's performance on three performance-based tests: 4-meter timed walk, five chair stands, and balance in three different standing positions side by side, semi-tandem, and full tandem. Participants will receive a score of 0 to 4 for each test. The summary performance score is the sum of scores calculated across the three tests, with 0 representing the worst and 12 the best.
次要结局
未报告次要终点
研究者
Chao A. Hsiung
Distinguished Investigator/Director
National Health Research Institutes, Taiwan