Measuring static and dynamic cerebral autoregulation intraoperatively in volunteers at different steady-state MBP. - Measuring cerebral autoregulation intraoperatively in volunteers.

Academisch Medisch Centrum0 个研究点目标入组 66 人开始时间: 待定最近更新: 2024年4月15日

适应症

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•ASA-I or ASA-II, willing and able to give written informed consent, scheduled for elective, non-cardiothoracic surgery under general anaesthesia and age 18 years and above.

•Patient related
•* Unable/ unwilling to participate
•* ASA-III or higher
•* Age < 18 years
•* History of: uncontrolled hypertension, diabetes, Parkinson*s disease, uncontrolled cardiac arrhythmia, Pure autonomic failure (formerly called idiopathic orthostatic hypotension), Multiple system atrophy with autonomic failure (formerly called Shy-Drager syndrome), Addison*s disease and hypopituitarism, pheochromocytoma, peripheral autonomic neuropathy (e.g., amyloid neuropathy, idiopathic autonomic neuropathy), known cardiomyopathy, extreme left ventricle hypertrophy or ejection fraction < 30%, proven or suspected allergy for any of the medication used during induction of anaesthesia, malignant hyperthermia.
•* Unability to record transcranial Doppler ultrasound due to anatomical variance (~5% of population)
•* Contra-indications for intravenous or inhalational anaesthesia.
•Surgery related
•* Day case surgery
•* Laparoscopy with CO2 insufflation
•* Extreme positioning during surgery (head-down/up tilt, lateral decubitus position, prone)
•* Surgery < 60 minutes.

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