临床试验/NCT04920435

NCT04920435已完成不适用

Prediction of the Response to Neoadjuvant Radiation Chemotherapy Through Texture Analysis Derived From Magnetic Resonance Imaging, Contrast Injection Computed Tomography and Positron Emission Tomography at 18-FDG in Locally Advanced Rectal Cancer

University Hospital, Brest3 个研究点分布在 1 个国家目标入组 124 人开始时间: 2019年1月2日最近更新: 2021年12月7日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University Hospital, Brest
入组人数: 124
试验地点: 3
主要终点: Prediction of the complete response (pCR) to neoadjuvant chemoradiotherapy

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

In patient with complete pathological response, surgery could be omitted without compromising progression-free or overall survival. A powerful prediction model is needed to guide management of this population.

Radiomics features provide complementary information about tumor heterogenity.

The aim of the investigators is to develop a model combining clinical and radiomic criteria able to predict complete pathological response.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Retrospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•locally advanced rectal cancer
•patients who received concomitant radio-chemotherapy followed by surgery
•pre-therapeutic MRI and CT-scan dicom available

排除标准

•age under 18 yo
•lack of MRI or CT-scan

结局指标

主要结局

Prediction of the complete response (pCR) to neoadjuvant chemoradiotherapy

时间窗: TO = Immediately after biopsy and extension evaluation.

defined as the absence of tumor residue on the surgical specimen, ypT0N0

次要结局

未报告次要终点

研究者

发起方

University Hospital, Brest

申办方类型

Other

责任方

Sponsor

研究点 (3)

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