Long-term Follow-up of Anterior Cruciate Ligament Injury
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Self reported knee function
研究概览
简要总结
Anterior cruciate ligament (ACL) rupture is one of the most common sports-related knee injuries. Because it is such a significant injury - requiring a long period of rehabilitation before the injured person is ready to return to physical activity, the burden of injury is high. This can help to explain why so much of orthopaedic research is devoted to evaluating the outcomes of ACL injury. However, while there has been extensive study of short-term (up to 5 years after injury) outcomes, few studies have followed patients beyond 15 years after their ACL injury. This is important because long-term follow-up can provide key insights to guide the information provided to newly injured patients (e.g. to help set realistic expectations of what the injured person can expect of their knee function in the future), and help us evaluate the efficacy of previous treatments.
The primary aim is to assess the influence of an acute ACL injury on knee function and quality of life, 32-37 years after the index injury. Approximately 300 patients injured between 1980 and 1985 will be invited to participate in the study. Patient- and clinician-reported outcomes, and radiographic osteoarthritis will be evaluated.
详细描述
Patients injuring their ACL between 1980 and 1985 have periodically been followed since the injury. Now, we plan to contact all patients and invite them to participate. The patients will be asked to
- complete a questionnaire battery
- visit the movement laboratory at Linköping University for an objective assessment of knee function and
- have an x-ray of both knee joints.
Baseline information including associated injuries, treatment and activity level exist for all the patients. At that time, rehabilitation was normally completed after 4-6 months for non-operatively treated patients, and nine months after ACL surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 47 Years 至 77 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •primary ACL injury between 1980 and 1985, age between 15 and 40 at injury
排除标准
- •all patients from the initial cohort will be invited for participation
结局指标
主要结局
Self reported knee function
时间窗: 32-37 years after ACL injury
Knee Injury and Osteoarthritis Outcome Score, KOOS 4 (Pain, Symptoms, Sport/Rec, QOL subscales)
Osteoarthritis
时间窗: 32-37 years after ACL injury
Development of osteoarthritis examined with tibiofemoral and patellofemoral radiographs
次要结局
- Quality of life(32-37 years after ACL injury)
- Physical activity(32-37 years after ACL injury)
- Objective assessment of knee function(32-37 years after ACL injury)
- Associated injuries and additional surgery(32-37 years after ACL injury)
研究者
Joanna Kvist
Professor
Linkoeping University