Effect of Low Frequency Ultrasound on Kidney Function

Not Applicable

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT02026544
• Lead Sponsor: Sonogenix

Brief Summary

The purpose of this study is to find out what effect, if any, Low Frequency Therapeutic Ultrasound (LOTUS) has on kidney function in patients with chronic kidney disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-12-19
• Study First Submitted QC: 2013-12-31
• Study First Posted: 2014-01-03
• Study Start: 2014-01-28
• Primary Completion: 2014-10-06
• Study Completion: 2014-10-06
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-20
• Last Update Posted: 2021-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Must be >/= 18 years of age
• Must have documented Stage 3 to Stage 4 (eGFR 15 - 59) chronic kidney disease
• Females with childbearing potential must not be pregnant at the time of study
• Subject must provide written informed consent

Exclusion Criteria

• Unable or unwilling to cooperate with study procedures
• Currently enrolled in another clinical study for which the follow-up period is not complete

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Glomerular Filtration Rate (GFR)	Baseline and 15 minutes after start of Intervention	Absolute change in glomerular filtration rate, GFR, measured by Tc-99m DTPA (diethylenetriamine pentaacetic acid) imaging (Gates Method) in the treated kidney(s) from baseline to during LOTUS

Secondary Outcome Measures

Name	Time	Method
Percent change in GFR	Baseline and 15 minutes after start of Intervention	Percent change in GFR in the treated kidney(s) from baseline to during LOTUS.
Blood Pressure	Baseline and 15 minutes after start of Intervention, and 5 minutes after end of intervention	Blood pressure is measured at baseline, during LOTUS intervention, and immediately after LOTUS intervention

Trial Locations

Locations (1)

Department of Radiology and Biomedical Imaging, UCSF; 🇺🇸 San Francisco, California, United States