ong term results (mortality, morbidity and quality of life) following neonatal surgical correction of esophageal atresia.

• Conditions: 10017943; 10017998; congenital esophageal obstruction; esophageal atresia; 10018018

• Registration Number: NL-OMON30122
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

age between 8 and 18 years
esophageal atresia OR
surgically treated gastro-esophageal reflux

Exclusion Criteria

mental retardation
prematurity (<35 wks)
recognized chronic respiratory diseases (such as cystic fibrosis)
syndromal and/or chromosomal disorders

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Pulmonary function parameters: forced expiratory volume in 1 second (FEV1),<br /><br>forced vital capacity (FVC), FEV1/FVC ratio, total lung capacity (TLC), vital<br /><br>capacity (VC), residual volume (RV) and diffusion capacity (DLCO)<br /><br>2. Maximal exercise test: oxygen saturation, aerobic capacity (VO2 max)<br /><br>3. Increased risk of gastro-esophageal reflux, based on standardised<br /><br>questionnaire<br /><br>3. Health related quality of life, hased on the Child Health Questionnaire. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>