Uterine Artery and Spiral Artery Doppler Parameters in Patients With Postmenopausal Bleeding
试验速览
- 阶段
- 不适用
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Uterine Artery Resistive Index According to Histological Diagnosis
研究概览
简要总结
This study was to investigate the diagnostic value of ultrasonography and blood flow measurements in uterine arteries and spiral arteries by transvaginal color Doppler ultrasonography in the detection of the endometrial pathology in women with postmenopausal bleeding.
详细描述
This prospective Cross-sectional Observational study will be conducted at the Department of Obstetrics and Gynecology, Banha University, Egypt during the period starting from January 2014. The study protocol will be approved by the Local Ethics Committee and written informed consent will be obtained from each patient before the study commenced.
Seventy patients with postmenopausal bleeding will be included in the study after verbal consent. They will be recruited from patients attending gynecologic clinic in Banha University hospital.
All patients will be subjected to the following:
For all included women the following will be done:
- Full history taking.
- Complete general, abdominal, and local examination.
- Ultrasonographic assessment of the uterus
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Endometrial thickness ≥ 5 mm measured by two-dimensional transvaginal ultrasound.
- •Pap smear is negative for malignancy.
排除标准
- •Postmenopausal woman on hormon replacement therapy.
- •Trans-vaginal examination not possible (Vaginal stenosis or patient refusing trans-vaginal ultrasound).
- •Adnexal pathology.
- •General causes of bleeding e.g: Hemophilia , anticoagulation therapy
研究组 & 干预措施
ultrasonography
Ultrasonographic assessment of the thickness of the endometrium of the uterus and transvaginal color Doppler ultrasonography for measurements of Pulsatility index and resistance indices of uterine arteries and spiral arteries
干预措施: Ultrasonography (Radiation)
结局指标
主要结局
Uterine Artery Resistive Index According to Histological Diagnosis
时间窗: two weeks
The primary outcome measures is uterine artery resistive index (RI) .In ultrasonography,it can be calculated from the peak systolic velocity and end diastolic velocity of blood flow and is calculated with the following formula: (peak systolic velocity - end diastolic velocity)/peak systolic velocity.lower values are better than higher values.
Uterine Artery Pulsatility Index According to Histological Diagnosis
时间窗: 2 weeks
Pulsatility index is a measure of the variability of blood velocity in a vessel, and was calculated as the difference between the peak systolic and end diastolic velocities divided by the mean velocity during the cardiac cycle. Higher values are indicative of increased vascular resistance
Endometrial Thickness According to Histological Diagnosis
时间窗: 2 weeks
Endometrial Thickness was assessed by measuring the trilaminar halo of the Endometrial Thickness by trans vaginal sonography
Pulsatility Indices (PI) of Spiral Artery According to Histological Diagnosis
时间窗: two weeks
Pulsatility index is a measure of the variability of blood velocity in a vessel, and was calculated as the difference between the peak systolic and end diastolic velocities divided by the mean velocity during the cardiac cycle. Higher values are indicative of increased vascular resistance
Resistive Indices (PI) of Spiral Artery According to Histological Diagnosis
时间窗: two weeks
The primary outcome measure is spiral artery resistive index (RI) .In ultrasonography,it can be calculated from the peak systolic velocity and end diastolic velocity of blood flow and is calculated with the following formula: (peak systolic velocity - end diastolic velocity)/peak systolic velocity.lower values are better than higher values.
次要结局
未报告次要终点