SARS-CoV-2 immune response in asymptomatic patients
Recruiting
- Conditions
- SARS-CoV-2
- Registration Number
- NL-OMON24645
- Lead Sponsor
- Amsterdam UMC, location AMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
Adult (age = 18 years)
-Screened for COVID-19 according to the national guidelines because of a planned surgical or interventional procedure under general anesthesia.
-Tested positive for SARS-CoV-2 with RT-PCR.
-Asymptomatic at the moment of screening: no suspicion for COVID-19 for at least 48 hours prior to screening, based on a standardized questionnaire containing the following complaints: cough, dyspnoea, fever, general malaise, myalgia, headache, extreme fatigue (new onset), throat ache, obstructed/runny nose, loss of smell, loss of taste, abdominal pain, diarrhoea and vomiting.
Exclusion Criteria
-Not able or willing to give informed consent.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary objective is to determine the quantity and quality of antibody and T-cell responses to SARS-CoV-2 in asymptomatic patients who tested positive for SARS-CoV-2 with RT-PCR prior to interventions.
- Secondary Outcome Measures
Name Time Method -To determine the level of serum antibody response to other (seasonal) coronaviruses.<br>-To evaluate the effect of age, comorbidity and RT-PCR cycling threshold values as predictors for immune responses to SARS-CoV-2. <br>-To evaluate the development of antibody and T-cell responses over time (up to one year after positive testing). <br>-To compare levels of antibody and T-cell responses to SARS-CoV-2 of asymptomatic patients with those of mild and severe symptomatic patients with laboratory-confirmed COVID-19