Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Maintained blood pressure
- Conditions
- Blood Pressure
- Sponsor
- Sahlgrenska University Hospital, Sweden
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- The magnitude and dynamics of the decrease in hematocrit during anesthesia induction
- Last Updated
- 11 years ago
Overview
Brief Summary
The arterial blood pressure affects the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the hematocrit. During induction of anesthesia blood pressure, hemoglobin level and hematocrit decreases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the decrease in hematocrit.
Detailed Description
24 patients scheduled for coronary artery bypass surgery will be included and randomized to receive either norepinephrine in the dose needed to maintain pre-anesthesia blood pressure or to a control group and receive norepinephrine only if mean arterial pressure decreases below 60 mmHg. Arterial blood gas will be analysed every ten minutes. Equal anesthesia in both groups will be monitored. No fluids will be infused. Noninvasive continuous hemoglobin measurement (SpHb) will be measured.
Investigators
Tor Damén
MD
Sahlgrenska University Hospital, Sweden
Eligibility Criteria
Inclusion Criteria
- •Elective coronary artery surgery patients
Exclusion Criteria
- •Age under 18 years
- •untreated hypertension
- •a reduced left ventricular systolic ejection fraction of 45 % or less
- •diabetes mellitus
- •former stroke and/or a known carotid artery stenosis.
Arms & Interventions
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
Intervention: Maintained blood pressure
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
Intervention: Norepinephrine
Outcomes
Primary Outcomes
The magnitude and dynamics of the decrease in hematocrit during anesthesia induction
Time Frame: 70 minutes from anesthesia induction
Secondary Outcomes
- Reduced hematocrit decrease by vasopressor infusion maintained blood pressure(70 minutes from anesthesia induction)