Pressure-dependent Changes in Hematocrit and Plasma Volume During Anesthesia

Not Applicable

• Conditions: Anesthesia; Blood Pressure; Hematocrit Change
• Interventions: Procedure: Maintained blood pressure; Drug: Norepinephrine

• Registration Number: NCT02412189
• Lead Sponsor: Sahlgrenska University Hospital, Sweden

Brief Summary

The arterial blood pressure affects the ratio between filtration and reabsorption of fluids in the circulating blood volume and thereby the hematocrit. During induction of anesthesia blood pressure, hemoglobin level and hematocrit decreases. The aim of the study is to evaluate weather a maintained blood pressure with norepinephrine during anesthesia induction reduces the decrease in hematocrit.

Detailed Description

24 patients scheduled for coronary artery bypass surgery will be included and randomized to receive either norepinephrine in the dose needed to maintain pre-anesthesia blood pressure or to a control group and receive norepinephrine only if mean arterial pressure decreases below 60 mmHg. Arterial blood gas will be analysed every ten minutes. Equal anesthesia in both groups will be monitored. No fluids will be infused. Noninvasive continuous hemoglobin measurement (SpHb) will be measured.

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2015-03-10
• Status Verified: 2015-04
• Primary Completion: 2015-04
• Study First Submitted QC: 2015-04-04
• Last Update Submitted: 2015-04-04
• Study First Posted: 2015-04-09
• Last Update Posted: 2015-04-09
• Study Completion: 2015-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Elective coronary artery surgery patients

Exclusion Criteria

• Age under 18 years
• untreated hypertension
• a reduced left ventricular systolic ejection fraction of 45 % or less
• diabetes mellitus
• former stroke and/or a known carotid artery stenosis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Maintained blood pressure	Maintained blood pressure	Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
Maintained blood pressure	Norepinephrine	Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion

Primary Outcome Measures

Name	Time	Method
The magnitude and dynamics of the decrease in hematocrit during anesthesia induction	70 minutes from anesthesia induction

Secondary Outcome Measures

Name	Time	Method
Reduced hematocrit decrease by vasopressor infusion maintained blood pressure	70 minutes from anesthesia induction	To assess if the decrease in hematocrit can be reduced, by maintaining the blood pressure with vasopressor infusion

Trial Locations

Locations (1)

Sahlgrenska University Hospital; 🇸🇪 Gothenburg, Sweden