A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicentric Trial
概览
- 阶段
- 3 期
- 干预措施
- rivastigmine
- 疾病 / 适应症
- Parkinson's Disease
- 发起方
- University Hospital, Lille
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Measure on the scale : Lille Apathy Rating Scale (LARS)
- 状态
- 已完成
- 最后更新
- 14年前
概览
简要总结
Apathy usually refers to a set of behavioural, emotional and cognitive features as a reduced interest and participation in main activities of daily life, a lack of initiative, a trend toward an early withdrawal from started activities, an indifference and a flattening of affect. We have validated a new specific scale (Lille Apathy Rating Scale, LARS) in order to detect and quantify apathy in Parkinson's disease (PD). Apathy was shown to be frequent in PD with a prevalence of 32%. It has suggested that the medial frontal and limbic cholinergic deficits may underlie apathy in neurodegenerative disorders like Alzheimer's disease (AD). Such a hypothesis is supported by recent evidence indicating the beneficial effects of cholinesterase inhibitors on neuropsychiatric symptoms, mainly apathy, in AD patients. As the efficacy of rivastigmine on cognition has also been shown in PD, we aimed to assess with a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial, the efficacy and acceptability of a 6 months treatment with rivastigmine on apathy in 60 patients with PD without dementia. The primary end point will be the LARS score and the secondary end points will be the cognitive, behavioural and motor symptoms of PD. Two add-on studies will be proposed: first the measure of choline and glutamate peaks on Magnetic Resonance Spectrometry focused on the structures implicated in apathy in order to give insights in the physiopathological mechanisms of the treatment. Secondly, the recording of the REM sleep behavior disorders in relation with the cholinergic part of the pedunculopontine nucleus. Regarding that apathy could be one of the first steps toward PD dementia, treating very early could have substantial implications on the patients and their caregiver.
详细描述
Overall study duration: 2 years. Planned inclusion period: 12 months. Study duration for individual patients: 7 months (2 weeks between screening and randomization, 6 months of double-blind treatment and then a 2-week wash-out period). Primary objective (V1 and V6): To assess efficacy of anticholinesterasic treatment (trans-dermal patch of rivastigmine , Exelon®) on parkinsonian apathy assessed by the Lille Apathy Rating Scale in patients with advanced Parkinson's disease without dementia or depression Additional Efficacy Endpoints (V1 and V6): * the NeuroPsychiatric Inventory, the apathy/retardation subscore of the MADRS (tri-dimensional analysis, the Activity of Daily Living scale, the simple and complex reaction times (selective attention), the quality of life (PDQ-39), the "Zarit" scale and the Clinical Global Impression of Change, Independence Scale, Mattis score, MMSE * Gait: time and number of steps and freezing at the Stand Walk Sit test, the Tinetti scale, the UPDRS I, II, III et IV, the self questionnaire of Giladi * Sleep quality: during two successive polysomnography recordings (sleep pattern, measures of the rapid eye movement (REM) sleep time, daytime sleepiness (PDSS and Epworth), and Sleep Latency Test * Magnetic Resonance Spectroscopy on the measures of the choline/creatine and glutamate/creatine peaks (medial frontal cortex, limbic cortex, caudate nucleus, putamen, pedunculopontine nucleus) on 3 Tesla MRI Safety and Tolerability Endpoints (V1, V3 and V6): Safety and tolerability will be evaluated with reference to the following: 1. Tolerability : Number of subjects (%) who discontinue the study, Number of subjects (%) who discontinue the study due to AEs. 2. Safety Measures : AE incidence, Safety laboratory values, Vital signs, Blood pressure monitoring, ECG, Physical and neurological examination. Study Design Multicentric pilot study: 36-week double blind, placebo-controlled phase. After being found eligible to participate in the study, subjects will be allocated in a 1:1 ratio into one of the following two treatment groups based on a randomization scheme with blocks stratified: 1. one patch of 4.6 mg/day during 1 month, then one patch of 9.5 mg/day during 5 months 2. one patch of placebo during 6 months Schedule: 7 visits * Four consultations: screening (V0), randomisation (V1, 15 days after V0), (V3) visit after 3 months and termination (V7, 6 months after randomisation) * Two phone calls (V2, V4) Patients : 60 subjects with Parkinson's disease duration of more than 5 years, without dementia (Mattis Dementia Rating Scale ≥ 130, MMSE ≥ 27 and DSM IV), without major depression (MADRS \< 18) who have developed apathy (defined by a score of - 16 or more at the LARS) despite an optimal dopaminergic treatment No additional therapy will be permitted during the study. Investigational Medicinal Product (IMP) \& Dosage: Rivastigmine, or matching placebo, administered by transdermal patch a day in the morning: 4.6 mg a day during one month, 9.5 mg a day during five months Centres : Lille : * Department of Neurology, University Hospital, Lille : Pr L. Defebvre, Pr K. Dujardin, Dr D. Devos, Pr Destee, Mme Delliaux. Dr A Kreisler, Dr C Simonin, Dr C. Moreau * Department of Pharmacology, Faculté de Médecine, Lille II : R. Bordet * Department of Clinical Neurophysiology, sleep laboratory : Pr P. Derambure, Dr C. Monaca * Department of Neuroradiology : Pr J. Pruvo Dr C. Delmaire Dr P. Jissendi, Dr G. Soto Ares, Pr X. Leclerc * Department of Statistics, CERIM, Faculté de Médecine Lille II : Dr P. Devos, Dr A. Duamel * Lille III University : Dr P. Sockeel Méthodologiste Amiens : - Department of Neurology, University Hospital, Amiens : Pr P. Krystkowiak, Pr O. Godefroy, Dr Gérard, Dr Dupuy, Pr Deramon, Pr JM Macron, Dr Rose Rouen : - Department of Neurology, University Hospital, Rouen, . Dr D. Maltête, Pr. D. Hannequin, Dr. O. Martinaud, Dr E. Gérardin, Pr. B. Mihout, Mmes C. Aubier-Girard, S Bioux, E. Bliaux, D. Pouliquen Caen : - Department of Neurology, University Hospital,Caen, : Pr G. Defer, Pr F. Viader, Dr Guillamo Dr Marié, Dr Carluer, Mme Lebrun
研究者
入排标准
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Active treatment
A: transdermal rivastigmine at 4.6 mg per day during one month then 9.5 mg per day during 5 months.
干预措施: rivastigmine
placebo
transdermal patch of placebo
干预措施: placebo
结局指标
主要结局
Measure on the scale : Lille Apathy Rating Scale (LARS)
时间窗: 6 months
measure of the reduction of apathy with this qualitative scale from -36 +36 with the cut off -16
次要结局
- Cognitive, motor and behaviour assessment(6 months)