Impact of a Capsular Incision on Biochemical Recurrence After Radical Perineal Prostatectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 266
- 试验地点
- 1
- 主要终点
- biochemical recurrence of prostate cancer
研究概览
简要总结
To evaluate the impact of capsular incisions on biochemical recurrence (BCR) and the potential risk factors of capsular incisions.
详细描述
The pathological classification of the prostate following radical prostatectomy provides important prognostic information; an accurate pathology report is the cornerstone to cancer treatment and follow-up. In addition to the preoperative serum PSA, Gleason score on pathology specimens, seminal vesicle invasion and lymph node status, and a positive surgical margin with extraprostatic extension (EPE) are significant predictors of clinical and biochemical recurrence. However, the prognostic implication of a capsular incision, a tumor extending to the inked margins without a histologically documented EPE, remains to be defined.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 43 Years 至 78 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •pathologically proven prostate cancer
- •follow-up for at least 6 months
排除标准
- •insufficient biopsy data
- •seminal vesicle invasion or lymph node involvement on pathology
- •neoadjuvant or adjuvant therapy
结局指标
主要结局
biochemical recurrence of prostate cancer
时间窗: upto the final date of study
次要结局
- risk factors for capsular incisions(at surgery)