Effect of vitamin B12 infusion in prevention of nitrous oxide- induced homocysteine increase
Not Applicable
- Conditions
- itrous oxide in general anesthesia.Poisoning by and exposure to other and unspecified drugs, medicaments and biological substances, undetermined intent
- Registration Number
- IRCT201209226803N3
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Informed written consent; ASA class ?-??; Age between 18 and 45 years; Elective surgeries that operation time is estimated at more than 2 hours.
Exclusion criteria: Pregnancy; Emergency Surgery; Contraindications of nitrous oxide )such as Pneumothorax; Mechanical intestinal obstruction; Occlusion of the middle ear; Laparoscopic Surgery; Laser Surgery; Increased ICP); Intake of vitamin B12 and folate supplements before surgery; Contraindications of vitamin B12 and folate; Leber's disease; Patients with vitamin B12 or folate deficiency; megaloblastic anemia; Anesthesia in the past month; Smoking; Renal failure; hypothyroidism.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Plasma homocysteine. Timepoint: before intervention, 24h after intervention. Method of measurement: blood sampling.
- Secondary Outcome Measures
Name Time Method ausa and vomiting. Timepoint: after intervention in the end of surgery. Method of measurement: Questionnaire.;Plasma vit B12. Timepoint: before intervention, 24h after intervention. Method of measurement: blood sampling.