Prevalence of Cerebral Large Vessel Occlusion Among Acute Ischemic Stroke Patients in Assiut University Hospitals

Prevalence of Large Vessel Occlusion among acute ischemic stroke patients in Assiut University hospitals

1. Study Objectives

Primary Objective:

- To determine the prevalence of LVO among acute ischemic stroke (AIS) patients presenting to Assiut University hospitals

Secondary Objectives:

• To describe clinical and radiological characteristics of LVO patients.
• To assess factors associated with LVO (age, sex, stroke severity, comorbidities).

2. Study Design

• Type: single center, prospective observational cross-sectional study
• Duration: 12-month recruitment period
• Setting: Assiut university hospitals, stroke unit.

3. Study Population

Inclusion Criteria:

• Adults (≥18 years)
• Diagnosed with acute ischemic stroke within 24 hours of symptom onset
• Underwent vascular imaging (CTA or MRA) on admission

Exclusion Criteria:

• Hemorrhagic stroke
• Stroke mimics
• Incomplete imaging data 4. Definitions

Large Vessel Occlusion (LVO) defined as occlusion in:

• Intracranial ICA
• M1 or proximal M2 segments of MCA
• Basilar artery ± Optional: A1 6. Data Collection

Clinical Data:

• Demographics (age, sex)
• Risk factors (HTN, DM, AF, CAD, smoking)
• NIHSS on admission and discharge mRS on admission and discharge
• Onset-to-door time
• Imaging modality used

Imaging Data:

• Site of occlusion
• ASPECTS (optional)
• Collateral status (optional if available)

Hospital Data:

• Facility type (public vs private)
• Door-to-CT and door-to-CTA times 8. Analysis Plan
• Primary: Prevalence of LVO = Number of LVO cases / Total AIS patients with vascular imaging
• Subgroup analysis: By age group, sex, region, NIHSS
• Secondary: Logistic regression to identify predictors of LVO