Using a Smartphone App to Target Current Mental Health Symptoms of Anxiety and Depression
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Depression
- Sponsor
- Trustees of Dartmouth College
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- Changes in depression as assessed by Patient Health Questionnaire-9
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This is a prevention intervention study that will examine the efficacy of a smartphone-based intervention in decreasing cancer risk by targeting mental health risk factors of anxiety and depression.
Detailed Description
This prevention intervention study aims to examine the efficacy of a smartphone-based intervention in decreasing cancer risk by targeting mental health risk factors of anxiety and depression. The study will utilize a smartphone application called Mood Triggers, designed to provide personalized feedback on individuals' maintenance factors (i.e., "triggers") of their anxiety and depressive symptoms. Mood Triggers delivers ultra-brief interventions (less than 2 minutes long) where participants view videos introducing important skills to treat their anxiety and depression. The study targets middle-aged adults (40-64 years old) who meet current criteria for moderate to severe anxiety and/or depressive disorders. It will enroll an anticipated 100 participants in a single-group, open-label design, with the intervention lasting up to 12 weeks. The primary outcomes include changes in depression and anxiety symptoms, measured by the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-Q-IV Scale, respectively, as well as changes in cancer risk assessed by the World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Score.
Investigators
Nicholas Jacobson
Assistant Professor of Biomedical Data Science and Psychiatry
Trustees of Dartmouth College
Eligibility Criteria
Inclusion Criteria
- •Middle-aged adults (age 40 to 64).
- •fluent in English.
- •Able to provide informed consent.
- •Meets current criteria for an anxiety and/or depressive disorder with severity ranging from moderate to severe (based on the Patient Health Questionnaire - 9 and the Generalized Anxiety Disorder Questionnaire).
- •Owns a smartphone.
Exclusion Criteria
- •Acute psychosis (based on the self-reported Structured Interview for Psychosis risk Syndromes, Prodromal Questionnaire - Brief version \[SIPS PQ-B\]).
- •Moderate to high suicidal ideation (based on a response of 2 or more on the PHQ-9 item-9).
- •History of bipolar disorder (based on the self-reported Mood Disorder Questionnaire \[MDQ\].
- •Past or current diagnoses of cancer.
- •Changes to treatments or medications in the past 30 days.
Outcomes
Primary Outcomes
Changes in depression as assessed by Patient Health Questionnaire-9
Time Frame: 12 weeks post-baseline
Possible PHQ-9 scores range from 0 to 27, with higher scores representing greater MDD symptom severity
Change in anxiety symptoms as assessed by Generalized Anxiety Disorder- Q-IV Scale
Time Frame: 12 weeks post-baseline
Possible GAD-Q-IV scores range from 0 to 12, with higher scores representing greater GAD symptom severity
World Cancer Research Fund (WCRF)/ American Institute for Cancer Research (AICR) Cancer Prevention Score.
Time Frame: Up to 12 weeks after enrollment
Minimum score: 0, Maximum score: 7-8 (8 for persons capable of breastfeeding). Greater scores suggest lower cancer risk.
Secondary Outcomes
- Smartphone estimates of sociability as mechanisms of change in cancer risk(Up to 12 weeks after enrollment)
- Momentary Assessment of Anxiety Symptom Changes(Up to 12 weeks after enrollment)
- Momentary Assessment of Behavioral Avoidance Symptom Changes(Up to 12 weeks after enrollment)
- Diet as mechanism of change in cancer risk(Baseline, 6 weeks post-baseline, 12 weeks post-baseline)
- Momentary Assessment of Arousal Symptom Changes(Up to 12 weeks after enrollment)
- Momentary Assessment of Depression Symptom Changes(Up to 12 weeks after enrollment)
- Momentary Assessment of Hopelessness Symptom Changes(Up to 12 weeks after enrollment)
- Smartphone estimates of motion activity as mechanisms of change in cancer risk(Up to 12 weeks after enrollment)