Assessment of lung derecruitment resulting from suction of the endotracheal tube in ventilated preterm infants

Not Applicable

Completed

• Conditions: Ventilated preterm infants; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12610000452099
• Lead Sponsor: Judy Hough

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-06-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Gestation less than 32 weeks gestation (i.e. up to and including 31 weeks 6 days gestation)
Less than 7 days of age at onset of endotracheal ventilation
Birth weight of more than 750 grams
Duration of ventilation at enrolment of at least 12 hours
Expected to continue to receive mechanical ventilation before and after at least one episode of airway suction after enrolment
Satisfactory endotracheal tube position has been determined by chest radiograph
Arterial sampling line in situ (umbilical or extremity)
Parent(s) able and willing to provide informed consent

Exclusion Criteria

Air leak syndrome (e.g. pneumothorax, pneumomediastinum, pulmonary interstitial emphysema
Lung or cardiovascular anomaly that would substantially affect oxygenation, lung recruitment or regional ventilation, e.g;
o cyanotic or other major congenital heart disease (not including Patent Ductus Arteriosus)
otracheo-oesphageal fistula
ospace occupying thoracic lesion such as diaphragmatic hernia or eventration, or cystic adenomatoid malformation
Substantial leak around endotracheal tube (e.g.. >50%) precluding accurate non-invasive measurement of respiratory function
Significant hemodynamic instability (untreated shock, hypovolemia, hypotension)
Poor skin integrity precluding the use of adhesive electrocardiogram (ECG) electrodes.
Survival considered unlikely (death considered imminent or inevitable).
Both parents of baby under 18 years of age due to the complexities of obtaining consent.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ventilation distribution using electrical impedance tomography (EIT).[EIT measurements will be taken for 60 seconds before suction, and at 15, 30, 45, 60, 75, 90 105, 120 minutes post suction. <br>A 10 minute EIT measurement will be taken during suction.]

Secondary Outcome Measures

Name	Time	Method
Physiological parameters such as heart rate (HR), respiratory rate (RR), oxygen saturation (SpO2), blood pressure (BP).<br>Ventilator parameters using the Draegar ventview program will be downloaded from the ventilator Oxygenation[Ventilator parameters and physiological variables will be downloaded continuously from before suction and continue until 2 hours post suction.]