Role of Metabolomics in the Diagnosis of Endometriosis
Completed
- Conditions
- Endometriosis
- Interventions
- Procedure: laparoscopic surgery, obtainment of biological samples
- Registration Number
- NCT02337816
- Lead Sponsor
- University of Cagliari
- Brief Summary
Endometriosis is one of the most common benign gynecological, affecting about 10% of premenopausal women. The pathophysiology of this disease is still not completely clear. Despite its prevalence, there is no blood test available for the diagnosis of endometriosis and the average delay time to diagnosis is 9.4 years.
Metabolomics is a scientific discipline that studies changes in metabolites related to the pathophysiology of the disease.
Aim of the study is to identify an alteration in the expression of the metabolites in women with endometriosis
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 54
Inclusion Criteria
- women of childbearing age ;
- written consent to laparoscopic surgery;
- written consent to the study .
Exclusion Criteria
- Suspicion or diagnosis of malignant disease
- Inability or unwillingness to provide written consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Controls laparoscopic surgery, obtainment of biological samples Patients will undergo laparoscopic surgery in order to treat benign gynecological diseases. Biopsies will be performed for histological confirmation of the disease. Samples of urine and blood,with the purpose to study metabolitis, will be collected before surgery. Endometriosis laparoscopic surgery, obtainment of biological samples Patients will undergo laparoscopic surgery in order to treat endometriosis. Biopsies will be performed for histological confirmation of the disease. Samples of urine and blood, with the purpose to study metabolitis, will be collected before surgery.
- Primary Outcome Measures
Name Time Method Plasma and urine concentration of metabolites At least one month after discontinuation of hormonal therapies , before laparoscopic surgery
- Secondary Outcome Measures
Name Time Method