Comparative study of efficacy of Diclofenac and ketoprofen transdermal patches for postoperative pain relief in post LSCS patients.

This randomized controlled trial aims to compare the efficacy of diclofenac and ketoprofen transdermal patches for postoperative pain management in patients undergoing lower segment cesarean section (LSCS) under spinal anesthesia. Postoperative pain after cesarean delivery can delay maternal recovery, breastfeeding, and early mobilization. Transdermal NSAID patches provide a noninvasive and convenient method of analgesic delivery with controlled drug release and fewer gastrointestinal side effects.

A total of 108 patients aged 18–40 years, ASA grade II, scheduled for elective or emergency LSCS under spinal anesthesia will be enrolled and randomly allocated into two groups. Group K will receive a Ketoprofen 30 mg transdermal patch, and Group D will receive a Diclofenac 100 mg transdermal patch. The patch will be applied over the deltoid region immediately after delivery of the baby.

Pain intensity will be assessed using the Visual Analogue Scale (VAS). If the VAS score exceeds 4, intravenous paracetamol (10 mg/kg) will be administered as rescue analgesia. Hemodynamic parameters, including heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure, and oxygen saturation, will also be monitored. Adverse drug reactions, if any, will be recorded.

The primary objective of the study is to compare the analgesic efficacy of diclofenac and ketoprofen transdermal patches in post-LSCS patients, while secondary objectives include assessment of hemodynamic changes and adverse drug reactions associated with these patches.

The results of this study may help identify a more effective and convenient postoperative analgesic modality for cesarean section patients, improving maternal comfort and recovery.