NCT06671054招募中2 期
A Randomized, Double Blind, Placebo-controlled, Dose Response, Phase II, Multicentre Trial to Evaluate the Efficacy and Safety of Oral AP1189 Administered at the Doses of 40, 70, or 100 mg for 12 Weeks in Combination With Methotrexate, in DMARD-naïve Participants With Early Rheumatoid Arthritis and Active Inflammation.
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 240
- 试验地点
- 11
- 主要终点
- Change in Disease Activity Score 28 (DAS28)-C-Reactive Protein (CRP)
研究概览
简要总结
The study is a randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.
详细描述
The purpose of the trial is to evaluate the efficacy, safety and tolerability of 12 weeks daily treatment of oral AP1189 at the doses of 40, 70, or 100 mg in combination with oral MTX compared to oral MTX alone.
The aim is to have 240 participants randomized to one of the 4 treatment groups, in a 1:1:1:1 ratio and treated with both AP1189/Placebo and MTX.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed and dated informed consent obtained before undergoing any trial-specific procedure.
- •Participants with definite RA diagnosis according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria.
- •Disease duration no longer than 6 months from diagnosis at the time of Baseline Visit and with a history of RA symptoms which does not exceed 18 months.
- •Participants must be naïve to any Disease-modifying anti-rheumatic drugs (DMARDs)
- •Participants with at least 6/68 tender and 6/66 swollen joints at Screening Visit and Baseline.
- •Participants with "high" disease activity as documented by a Disease Activity Score 28 (DAS28) (C-Reactive Protein - CRP) index score > 5.1 at screening, and Clinical disease activity index (CDAI) >22 at Screening Visit and Baseline.
- •Participants with serum high sensitive C-Reactive Protein (hsCRP) ≥3 mg/L at the time of screening.
- •Participants positive for serum rheumatoid factor (RF), AND/OR anti-cyclic citrullinated peptide antibodies (anti-CCP). If seronegative RA, hsCRP ≥6 mg/L at the time of screening.
- •Willing and able to comply with the scheduled study visits, the treatment plan, and all study procedures.
- •Females of childbearing potential must have a negative pregnancy test at screening and again at baseline.
- •Sexually active female participants of childbearing potential and male participants are excluded if not practicing two different methods of birth control with their partner during the study and for 90 days after the last dose of study drug or who will not remain abstinent during the study and for 90 days after the last dose.
排除标准
- •Functional class IV of Global Functional Status in RA, as defined by the ACR Classification.
- •Rheumatic autoimmune disease other than RA, i.e. systemic lupus erythematosus, mixed connective tissue disease, scleroderma, polymyositis, or significant systemic involvement secondary to RA.
- •Current inflammatory joint disease other than RA.
- •Non-inflammatory type of musculoskeletal condition that in the Investigator's opinion is symptomatic and/or severe enough to interfere with the subject's primary diagnosis of RA or the evaluation of the effect of the study drug.
- •Gastrointestinal diseases known to interfere with the absorption or excretion of medications.
- •Severe, progressive, or uncontrolled renal, hepatic, hematologic, gastrointestinal, metabolic, endocrine, pulmonary, cardiac or neurologic disease.
- •Malignancy active during the 12 months preceding the Screening Visit.
- •Acute hepatitis, chronic hepatitis, or detection of any unexplained elevation of serum ALT or AST greater than 1.5-fold ULN, at least twice in the 6 months before the Screening Visit) or HIV infection.
- •History of alcohol or drug abuse during the 12 months preceding the Screening Visit.
- •Vaccination with live vaccines during the 6 weeks preceding the Screening Visit.
- •Haemoglobin <9 g/dL or Haematocrit <30% at the Screening Visit
- •White blood cell (WBC) count <3.0 x 109/L at the Screening Visit.
- •Absolute neutrophil count <1.2 x 109/L at the Screening Visit.
- •Platelet count <100 x 109/L at the Screening Visit.
- •Serum alkaline-phosphatase, or gamma-glutamyl-transferase greater than 3-fold ULN; alanine aminotransferase, or aspartate aminotransferase, or total bilirubin greater than 2-fold ULN At the Screening Visit.
- •Estimated creatinine clearance less than 45 mL/min/1.73 m2 (MDRD) at the Screening Visit.
- •12-lead electrocardiogram (ECG) with abnormal clinically significant findings, as judged by the Investigator, at the Screening Visit.
- •Positive QuantiFERON-in-Tube test (QFG-IT).
- •Use of hydroxychloroquine during the 30 weeks preceding the Screening Visit.
- •Treatment with any systemic or intraarticular corticosteroid within 6 weeks before the Screening Visit.
- •Intermittent use of nonsteroidal anti-inflammatory drugs (NSAIDs). Use of NSAIDs is allowed if used in a stable dose regimen for at least 4 weeks prior to the Screening Visit.
- •Use of other investigational drugs/treatments, or enrolment in a clinical trial during the 6 months preceding the Screening Visit.
- •Any other clinically relevant disease and condition that, in the opinion of the Investigator, may jeopardize efficacy or safety assessments or may compromise the subject's safety during trial participation.
研究组 & 干预措施
AP1189 40 mg
Experimental
12 weeks daily treatment of oral AP1189 40 mg as add-on to Methotrexate (MTX)
干预措施: AP1189, 40 mg (Drug)
AP1189 70 mg
Experimental
12 weeks daily treatment of oral AP1189 70 mg as add-on to Methotrexate (MTX)
干预措施: AP1189, 70 mg (Drug)
AP1189 100 mg
Experimental
12 weeks daily treatment of oral AP1189 100 mg as add-on to Methotrexate (MTX)
干预措施: AP1189, 100 mg (Drug)
Placebo
Experimental
12 weeks daily treatment of oral AP1189 matching placebo as add-on to Methotrexate (MTX)
干预措施: AP1189 matching placebo (Drug)
结局指标
主要结局
Change in Disease Activity Score 28 (DAS28)-C-Reactive Protein (CRP)
时间窗: Week 12
Absolute change from baseline in DAS28-CRP at Week 12
次要结局
未报告次要终点
研究者
研究点 (11)
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