Role of Hyaluronic Acid in Bone Healing After Dental Extraction

Not Applicable

Completed

• Conditions: Patients With Dental Extraction
• Interventions: Drug: Hyaluronic Acid

• Registration Number: NCT02330822
• Lead Sponsor: Damascus University

Brief Summary

This is a randomized controlled trial with a split mouth design. Patients with an indication of lower dental extraction will be asked to join this research project at the Department of Oral and Maxillofacial Surgery at University of Damascus Dental School. Each patient whose case requires bilateral extraction, one side will serve as an experimental side, whereas the other side will serve as a control.

Participants should have symmetric teeth that need extraction in the lower jaw. Hyaluronic acid will be injected following extraction in one of the two sides with random allocation.

cone-beam computerized tomography (CBCT) images will be taken for each participant immediately post-extraction and at six months post-operatively.

Detailed Description

I- Clinical examination variables:

Buccolingual distance and distomesial distance will be measured for each participant at 2 assessment times: directly post-extraction and six months post-extraction.

II- Radiographic examination variables:

Linear measurements Vertical bone fill Bone mineral density

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2015-01-01
• Study First Submitted QC: 2015-01-02
• Study First Posted: 2015-01-05
• Primary Completion: 2015-08
• Status Verified: 2015-09
• Study Completion: 2015-09
• Last Update Submitted: 2015-09-26
• Last Update Posted: 2015-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 18-60 years old
• Symmetric teeth requiring extraction in the lower jaw
• Systematically healthy

Exclusion Criteria

• Smokers
• Pregnancy (for female participants)
• Diabetic patients
• Patients with metabolic problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Hyaluronic Acid Group	Hyaluronic Acid	In this Group, Hyaluronic acid will be injected following extraction.

Primary Outcome Measures

Name	Time	Method
Vertical bone fill	This variable is going to be measured at 6 months post-extraction	'Vertical bone fill' is the distance between the base of the extraction socket and cement-enamel junction directly after extraction and minus the distance between base of the extraction socket and cement-enamel junction six months post-extraction.; This variable is going to be measured on CBCT images.
Change in bone mineral density (BMD)	(BMD) will be measured two times in this study: directly at the day of extraction and six months post-extraction.	BMD is the amount of bone tissue in a certain volume of bone. This variable is going to be measured on CBCT images.

Secondary Outcome Measures

Name	Time	Method
Buccolingual distance	at six months post-extraction	Buccolingual distance is the distance between buccal wall and lingual wall of the extraction socket. This variable is going to be measured clinically.
Mesiodistal distance	at six months post-extraction	Mesiodistal distance is the distance between mesial wall and distal wall of the extraction socket. This variable is going to be measured clinically.

Trial Locations

Locations (1)

Department of Oral and Maxillofacial Surgery, University of Damascus Dental School; 🇸🇾 Damascus, Damscus, Syrian Arab Republic