A Clinical and Experimental Study to Evaluate the Efficacy of Locally Applied Hyaluronic Acid in Bone Healing Following Dental Extraction
Overview
- Phase
- Not Applicable
- Intervention
- Hyaluronic Acid
- Conditions
- Patients With Dental Extraction
- Sponsor
- Damascus University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Vertical bone fill
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This is a randomized controlled trial with a split mouth design. Patients with an indication of lower dental extraction will be asked to join this research project at the Department of Oral and Maxillofacial Surgery at University of Damascus Dental School. Each patient whose case requires bilateral extraction, one side will serve as an experimental side, whereas the other side will serve as a control.
Participants should have symmetric teeth that need extraction in the lower jaw. Hyaluronic acid will be injected following extraction in one of the two sides with random allocation.
cone-beam computerized tomography (CBCT) images will be taken for each participant immediately post-extraction and at six months post-operatively.
Detailed Description
I- Clinical examination variables: Buccolingual distance and distomesial distance will be measured for each participant at 2 assessment times: directly post-extraction and six months post-extraction. II- Radiographic examination variables: Linear measurements Vertical bone fill Bone mineral density
Investigators
Eligibility Criteria
Inclusion Criteria
- •18-60 years old
- •Symmetric teeth requiring extraction in the lower jaw
- •Systematically healthy
Exclusion Criteria
- •Pregnancy (for female participants)
- •Diabetic patients
- •Patients with metabolic problems
Arms & Interventions
Hyaluronic Acid Group
In this Group, Hyaluronic acid will be injected following extraction.
Intervention: Hyaluronic Acid
Outcomes
Primary Outcomes
Vertical bone fill
Time Frame: This variable is going to be measured at 6 months post-extraction
'Vertical bone fill' is the distance between the base of the extraction socket and cement-enamel junction directly after extraction and minus the distance between base of the extraction socket and cement-enamel junction six months post-extraction. This variable is going to be measured on CBCT images.
Change in bone mineral density (BMD)
Time Frame: (BMD) will be measured two times in this study: directly at the day of extraction and six months post-extraction.
BMD is the amount of bone tissue in a certain volume of bone. This variable is going to be measured on CBCT images.
Secondary Outcomes
- Buccolingual distance(at six months post-extraction)
- Mesiodistal distance(at six months post-extraction)