Stress Hyperglycemia as a Prognostic Factor in Acute Ischemic Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- National Institutes of Health Stroke Scale (NIHSS)
研究概览
简要总结
Whereas diabetes mellitus is clearly a risk factor for the occurrence of stroke and for its poor prognosis, hyperglycemia per se is also linked to increased morbidity and mortality in stroke patients.Therefore, the objective of this work was to study the glycemic status of acute ischemic stroke patients and to assess its impact on stroke outcome.
详细描述
Using PASS program, setting alpha error at 5% and power of 80%, the total sample size was estimated to be 80 cases.
The NIHSS was used as a primary outcome; 40 cases were needed in each group. Secondary outcomes were hemorrhagic transformation, hospital stay duration, mechanical ventilation, need for vasopressors, and 30-days mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute ischemic stroke within 24 hours of onset of symptoms
排除标准
- •subdural hematoma
- •Transient ischemic attack
- •Subarachnoid hemorrhage
- •Hemorrhagic stroke
- •Major comorbidities Hyperglycemia on admission that was controlled (random blood sugar (RBS) < 150 mg/dl) within 24 hours with insulin therapy, diabetic
- •Ketoacidosis
- •RBS less than 70 mg/dl on admission
结局指标
主要结局
National Institutes of Health Stroke Scale (NIHSS)
时间窗: 30 days
The NIHSS score categorized into: no stroke symptoms (0), mild stroke (1-4), moderate stroke (5-15), moderate to severe stroke (16-20), and sever (21-42)
次要结局
- 30-days mortality(30 days)
研究者
Hanaa Mohamed Abdallah ElGendy MD
Assistant Professor
Ain Shams University