Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Changes in blood oxygenation level dependency (BOLD)
研究概览
简要总结
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.
详细描述
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.
Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is between 20-55 years old
- •Participant is not pregnant
排除标准
- •Participant is not able to consent him/herself
- •Suspected or proven pregnancy
- •Neurological diseases that could interfere with a diagnosis of ADHD
- •Psychiatric comorbidity under treatment
- •Previous history of psychiatric medication
- •Substance abuse
- •Intelligence quotient<75
- •Claustrophobia
- •Electrical simulator nerve or bone
- •Implanted medication infusion pump
- •Cerebral aneurysm clips
- •Unstable medical condition
结局指标
主要结局
Changes in blood oxygenation level dependency (BOLD)
时间窗: 2 hours
The study consist solely of one MRI examination performed within 2 hours.
次要结局
未报告次要终点
研究者
Luca Remonda
Prof. Dr. med.
Kantonsspital Aarau