Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD)
- Sponsor
- Kantonsspital Aarau
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Changes in blood oxygenation level dependency (BOLD)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.
Detailed Description
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood. The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested. Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.
Investigators
Luca Remonda
Prof. Dr. med.
Kantonsspital Aarau
Eligibility Criteria
Inclusion Criteria
- •Participant is between 20-55 years old
- •Participant is not pregnant
Exclusion Criteria
- •Participant is not able to consent him/herself
- •Suspected or proven pregnancy
- •Neurological diseases that could interfere with a diagnosis of ADHD
- •Psychiatric comorbidity under treatment
- •Previous history of psychiatric medication
- •Substance abuse
- •Intelligence quotient\<75
- •Claustrophobia
- •Electrical simulator nerve or bone
- •Implanted medication infusion pump
Outcomes
Primary Outcomes
Changes in blood oxygenation level dependency (BOLD)
Time Frame: 2 hours
The study consist solely of one MRI examination performed within 2 hours.