Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Completed

• Conditions: Liver Transplantation

• Registration Number: NCT01379352
• Lead Sponsor: Samsung Medical Center

Brief Summary

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may also be different according to the preoperative hepatic function as measured by MELD score during prehepatic phase, or graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, the investigators are trying to investigate the difference of vecuronium requirements according to the phase of surgery or MELD score, GRWR.

Detailed Description

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may by further reduced during anhepatic phase of liver transplantation. And the requirements may be increased as the graft functions during neohepatic phase.

We also postulated that the requirements may be different according to the preoperative hepatic function during preanhepatic phase, and according to the graft to recipient body weight ratio (GRWR) during neohepatic phase.

Therefore, we are trying to investigate the difference of vecuronium requirements according to the phase of surgery, MELD score, GRWR.

Study Timeline

• Study Start: 2011-06
• Study First Submitted: 2011-06-21
• Study First Submitted QC: 2011-06-22
• Study First Posted: 2011-06-23
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2013-12
• Last Update Submitted: 2013-12-24
• Last Update Posted: 2013-12-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• patients undergoing elective living donor liver transplantation

Exclusion Criteria

• patients who can not undergo train-of-four test due to central or peripheral neuromuscular disease.
• patients with severe cardiopulmonary diseases.
• patients who received transfusion with more than 10 units of packed red blood cells.
• primary non-functioning graft immediately after reperfusion of the graft.
• patients who administered drugs that influences the metabolism of vecuronium (such as anticonvulsant: phenytoin, carbamazepine, primidone, sodium valproate)
• patients undergoing cadaver donor liver transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
vecuronium requirements during neohepatic phase	during neohepatic phase of liver transplantation	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during neohepatic phase
vecuronium requirements during preanhepatic phase	during prehepatic phase of liver transplantation	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during preanhepatic phase
vecuronium requirements during anhepatic phase	during anhepatic phase of liver transplantation	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during anhepatic phase

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of