Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
Phase 2
- Conditions
- Supranuclear Palsy, Progressive
- Registration Number
- NCT00139373
- Lead Sponsor
- Groupe Hospitalier Pitie-Salpetriere
- Brief Summary
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and cholinergic systems, in particular in the Meynert basalis nucleus. This could participate in the occurrence of the distractibility in these patients. The aim of this study is to evaluate the effect of the donepezil, an anticholinesterase, on the distractibility in PSP patients, by using oculomotor and neuropsychological assessments.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Patients with PSP
- Age > 30 years old
- Disease duration < 5 years
- Mini mental state (MMS) > 24
- Antisaccades %: 40-80%
Read More
Exclusion Criteria
- Other parkinsonian syndromes
- MMS < 24
Read More
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre d'Investigation Clinique-HÔPITAL PITIÉ-SALPETRIERE
🇫🇷Paris, France