Predisposing Factors for Post-stroke Epilepsy

Recruiting

• Conditions: Post Stroke Epilepsy; Seizures; Stroke; Epilepsy

• Registration Number: NCT05864547
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The goal of this observational study is to learn about epilepsy after a stroke (post-stroke epilepsy). The main questions it aims to answer are:

* What make some patients develop epilepsy after a stroke?

* Does sleep have an impact on the development of post-stroke epilepsy?

Participants will undergo:

* Electroencephalography (EEG)

* Magnetic resonance imaging (MRI)

* Polysomnography (only patients)

Blood tests will also be taken. The patient group will be compared to the healthy controls. Researchers will also look into medical records of stroke patients hospitalized at St. Olavs hospital and collect relevant information.

Detailed Description

This study aims to study risk factors and clinical factors which might contribute to the development of post-stroke epilepsy. Researchers will look at the volume and size of the stroke-induced brain lesions and analyze inflammation markers. Patients and controls will undergo EEG and MRI. The correlations between sleep and epilepsy after a stroke will also be investigated through polysomnography. Relevant information about for instance age, comorbidities and NIHSS will be collected. Researchers will also collect relevant information from medical records of stroke patients hospitalized at St. Olavs hospital.

Study Timeline

• Status Verified: 2023-05
• Study Start: 2023-05-08
• Study First Submitted: 2023-05-09
• Study First Submitted QC: 2023-05-09
• Study First Posted: 2023-05-18
• Last Update Submitted: 2023-05-19
• Last Update Posted: 2023-05-22
• Primary Completion: 2030-12
• Study Completion: 2030-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• First time stroke patients with capacity to consent, admitted to the stroke unit at St. Olavs hospital.
• Modified Rankin Scale (mRS) ≤ 2 before the stroke

Exclusion Criteria

• Previous stroke or brain surgery
• Traumatic brain injuries
• Neurodegenerative diseases
• Brain tumors
• Epilepsy before the stroke
• Hydrocephalus
• Aphasia
• Serious psychiatric disorders
• MRI incompatibility and claustrophobia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Post-stroke epilepsy	6 months	Minimum one documented case of post-stroke epilepsy after the stroke

Secondary Outcome Measures

Name	Time	Method
Acute symptomatic seizure	14 days	Minimum one documented case of acute symptomatic seizure with epileptogenic activity recorded with EEG

Trial Locations

Locations (1)

St. Olavs Hospital Stroke Unit; 🇳🇴 Trondheim, Norway