Efficacy of I/v Nalbuphine v/s Iv Lignocain in Attanuation of Pressor Responseduring Laryngeoscopy and Intubation in Middle Age Patient Planned for Thyroid Surgery

Early Phase 1

Not yet recruiting

• Conditions: Hemodynamic Stability
• Interventions: Drug: Lignocaine

• Registration Number: NCT05298761
• Lead Sponsor: Sheikh Zayed Medical College

Brief Summary

Comparison of I/V nalbuphine versus I/V xylocain in attanuation of pressor response during intubation and laryngeoscopy in patients undergoing for thyroid surgery,selection of better supressor agent minimises the drug repated side effects like hypertention tachycardia but also helps in heamodynamically stability at induction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-02-22
• Study First Submitted QC: 2022-03-17
• Study First Posted: 2022-03-28
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-20
• Last Update Posted: 2023-11-21
• Study Start: 2023-12-30
• Primary Completion: 2024-03-01
• Study Completion: 2024-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• middle age(18_40)
• Asa 1 and 2
• Non hypertensive
• Thyroid patients
• patient who gives consent

Exclusion Criteria

• hypertensive
• Asa 3 and 4
• Patient refusal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lignocain	Lignocaine	I/V lignocain 1.5mg per kg given to participants in state dose
nalbuphine	Lignocaine	I/v nalbuphine 0.1mg per kg given to participants in stat dose

Primary Outcome Measures

Name	Time	Method
Reduce stress response during intubation and hemodynamic stabilty	10 minutes	Assesment of Hemodynamic stability by observing vital signs
Achieve hemodynamic stabilty and smooth intubation	10 minutes	Assesment of hemodynamic stability by clinical examination of vital signs

Trial Locations

Locations (1)

Dr.amna; 🇵🇰 Rahim Yar Khan, Punjab, Pakistan