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临床试验/NCT01550536
NCT01550536已完成不适用

Aging and Basal Metabolic Rate in Postmenopausal Women: Effects of Long-Term and Short-Term Physical Activity

University of California, San Diego6 个研究点 分布在 1 个国家目标入组 49 人开始时间: 2008年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
49
试验地点
6
主要终点
Change in basal metabolic rate

研究概览

简要总结

The primary purpose of this study is to expand research on the effects of physical activity on basal metabolic rate (BMR) in healthy postmenopausal women, and to further compare the effects of long-term habitual exercise to the results of a shorter-term (16 weeks) training program. The investigators will measure BMR by indirect calorimetry and normalize it across subjects for body size (fat free mass) and level of aerobic fitness (VO2MAX). Two groups will be compared: an intervention group (no previous participation in regular exercise, newly enrolled in this study's 16 week training program), and a long-term athlete group (have engaged in at least 5 hours of exercise per week for the past 10 years or longer). A secondary aim is to generate an equation for the prediction of BMR from fat free mass in physically active postmenopausal women, to be applied to hypotheses in biological anthropology. The investigators expect to find at baseline that, controlling for fat free mass and VO2MAX, the long-term group will have significantly higher BMR than the intervention group. At 16 weeks the investigators expect no change in BMR for the long-term group, while BMR will have increased in the intervention group. At the same time, the investigators expect to find that after completing the training regimen, the intervention group will have BMR similar to that of the long-term athletes.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
40 Years 至 120 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • naturally postmenopausal (i.e. non-surgically)/> 1 year since last menstruation
  • FSH > 30 mIU/ml
  • estradiol-17β < 25 pg/ml

排除标准

  • smoker, abuser of alcohol/other drugs
  • hypo- or hyperthyroid (serum TSH < 0.3 or > 5.5 microU/ml, respectively)
  • underweight or severely obese (BMI < 18.5 or > 35 kg/m2, respectively)
  • weight instability within the past six months (±> 5% of body weight)
  • hormone replacement therapy within the past six months
  • history of metabolic, respiratory or cardiovascular disease
  • high blood pressure
  • contraindication for maximal aerobic testing as determined by PAR-Q questionnaire and physician's examination

结局指标

主要结局

Change in basal metabolic rate

时间窗: baseline, 5, 10 and 16 weeks

Basal metabolic rate is the energy expended at rest and under fasting conditions.

次要结局

  • Change in fat-free mass(baseline, 5, 10 and 16 weeks)
  • Change in maximal aerobic capacity(baseline, 16 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Andrew Froehle

Doctoral Candidate

University of California, San Diego

研究点 (6)

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