Efficacy and safety of combination treatment of fractional carbon dioxide laser and acellular dermal matrix in the treatment of acne scars: A split-face, randomized controlled trial
- Conditions
- Acne scars
- Registration Number
- TCTR20220217008
- Lead Sponsor
- Department of Dermatology, Faculty of Medicine Siriraj Hospital
- Brief Summary
At 1-, 3- and 6-months follow-up, both intervention (I) and control (C) sides were improved in terms of scar volume, pore volume and roughness with statistical significance. Acne scar volumes were reduced by 20.3% (I) versus 17.0% (C), and 22.6% (I) versus 20.1% (C) at 3- and 6-months follow-up respectively. No serious complication were observed in either group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 28
1.Moderate acne scar grading from global acne scar grading system both side of the dace for 3 months
2.Fitzpatrick skin type 3-5
1.photosensitive dermatoses, Skin malignancy, keloid, immunocomporomised host, dermatitis or infeaction at treatment area
2.regular smoking
3.Pregnancy and lactating woman first 3 months
4.Cannot come back for follow up
5.AHA, retinoic acid or topical agents for acne scar within 6 months
6.Laser, RF within 3 months
7.Systemic steroid, immunosuppressive agents within 6 months
8. Oral isotretinoin within 12 months
9.Cannot sign her/his name on inform consent sheet
10.allergic to acellular dermal matrix / silicone (Megaheal)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method scar depression volume at 1 months, 3 months and 6 months after intervention Antera 3D camera
- Secondary Outcome Measures
Name Time Method safety at 1 months, 3 months and 6 months after intervention history tajing and physical examination