Inflammatory Biomarkers in Saliva at Depression

Completed

• Conditions: Inflammatory Response; Gingivitis; Depression; Inflammation
• Interventions: Other: Periodontal clinical measurements, Saliva sampling

• Registration Number: NCT06427902
• Lead Sponsor: Medipol University

Brief Summary

The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis.

The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?

Detailed Description

Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals.

Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits.

depression regardless of periodontal status.

Study Timeline

• Study Start: 2018-12-10
• Primary Completion: 2019-06-14
• Study Completion: 2019-09-16
• Status Verified: 2024-05
• Study First Submitted: 2024-05-16
• Study First Submitted QC: 2024-05-22
• Last Update Submitted: 2024-05-22
• Study First Posted: 2024-05-24
• Last Update Posted: 2024-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Patients who were moderate in severity according to the test result, who had not started drug therapy yet and who had not received antidepressant medication in the last 12 months

Exclusion Criteria

Patients with

• psychotic disorders
• autism spectrum disorders
• other anxiety disorders
• bipolar disorder
• mental any organic mental disorder and
• smokers, substance users

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
depression with periodontally healthy (DPH) patients	Periodontal clinical measurements, Saliva sampling	The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders.
depression with gingivitis (DG) group	Periodontal clinical measurements, Saliva sampling	The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders. the gingivitis group was determined by the criteria of pocket depth of 3 mm or less.
systemically and periodontally healthy (SPH) individuals	Periodontal clinical measurements, Saliva sampling	This group contists of individuals who are systemically and periodontally healthy

Primary Outcome Measures

Name	Time	Method
Salivary PGLYRP1	06-09 2019	Both, soluble and membrane-bound PGLYRP1 are detected by the PGLYRP1 ELISA.
SalivaryTREM-1	06-09 2019	Both, soluble and membrane-bound TREM-1, are detected by the TREM-1 ELISA.
Salivary IL-1β	06-09 2019	Both, soluble and membrane-bound IL-1β detected by the IL-1β ELISA.

Trial Locations

Locations (1)

Duygu Ilhan; 🇹🇷 Istanbul, Select State, Turkey