Dacarbazine and Ipilimumab vs. Dacarbazine With Placebo in Untreated Unresectable Stage III or IV Melanoma
- Registration Number
- NCT00324155
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The purpose of this clinical research study is to examine the safety and effectiveness (how well the drug works) of two different treatments for patients with melanoma. One treatment is an investigational compound (a drug that is not currently approved by the United States Food and Drug Administration \[FDA\]), know as Ipilimumab (also known as MDX-010 or BMS-734016) together with an approved chemotherapy drug called Dacarbazine
- Detailed Description
For the extension phase:
Allocation: single arm study; Masking: open label; Intervention Model: Single Group
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 681
- Informed Consent
- Measurable Disease
- Eastern Cooperative Oncology Group (ECOG) 0 or 1
- Lab / imaging requirements
- Neg for Human Immunodeficiency Virus (HIV), Hepatitis B (HepB), C
- Men and Women > 18 years (16 were allowable)
- Prior therapy restriction (adjuvant only)
Exclusion:
- Pregnant / nursing
- Inadequate contraception
- Brain metastasis
- Primary ocular or mucosal melanoma
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm B: Placebo and Dacarbazine Placebo - Arm A: Ipilimumab and Dacarbazine Ipilimumab In Maintenance phase: Ipilimumab will be continued. Dacarbazine was given up to Week 22 and is not given in the Maintenance phase Arm A: Ipilimumab and Dacarbazine Dacarbazine In Maintenance phase: Ipilimumab will be continued. Dacarbazine was given up to Week 22 and is not given in the Maintenance phase Arm B: Placebo and Dacarbazine Dacarbazine -
- Primary Outcome Measures
Name Time Method Overall Survival (OS) Date of randomization to 37 months through 5-year follow-up and up to approximately 76 months OS was defined as the time from the date of randomization until the date of death. Analysis of OS was to be done once 416 deaths had occurred (primary endpoint). However, analysis occurred at 414 deaths (February 7, 2011), due to operational timing of the study. Median number of months of OS and associated confidence interval calculated using the method of Brookmeyer and Crowley.
- Secondary Outcome Measures
Name Time Method Disease Control Rate (DCR) First dose to last tumor assessment prior to subsequent therapy at data cutoff for Primary Endpoint (approximately 5 years) DCR=number whose best overall response (BOR) was partial response (PR), complete response (CR) or stable disease (SD), divided by all randomized participants (unevaluable participants included). Independent review committee assessment. BOR=date of first dose to last tumor assessment prior to subsequent cancer therapy (including tumor resection, excluding palliative local radiotherapy). Modified World Health Organization criteria: CR=disappearance of all lesions; no evidence of progressive disease (PD); PR=50% or more decrease in the sum of products of the longest diameter and greatest perpendicular diameter of all index lesions compared with baseline; SD=neither sufficient decrease to qualify for PR nor sufficient increase to qualify for PD; PD=at least 25% increase in sum of products of all index lesions and/or appearance of any new lesions; nonindex lesions: appearance of any new lesions and/or unequivocal progression of nonindex lesions.
Median Number of Months of Progression-free Survival (PFS) Randomization to date of progression or death to approximately 5 years PFS=time between randomization and date of progression or death, whichever occurs first. Participants who died without reported prior progression were considered to have progressed on date of death. For those alive and not progressed, PFS was censored on date of last evaluable tumor assessment (TA). Those who have not died and have no recorded postbaseline TA were censored at randomization. Those who died without any recorded postbaseline TA were considered to have progressed on date of death. Evaluation was conducted by both investigator and an independent review committee (IRC), who assessed radiologic imaging studies, photographs of skin lesions, and clinical data. Progressive disease defined using modified criteria of the World Health Organization: demonstration of at least a 25% increase in the sum of products of all index lesions or the appearance of any new lesions. For nonindex lesions: appearance of any new lesions or unequivocal progression of nonindex lesions.
Survival Rate at 1 Year, 18 Months, 2 Years, and 3 Years Date of randomization to 3 years following randomization The survival rate (percentage of participants alive) was defined as the probability that a participant is alive at 1 year (or 18 months, 2 years, or 3 years) following randomization and was estimated via the Kaplan-Meier method.
Progression-free Survival (PFS) Rate Truncated at Week 12 Day 78 PFS rate=probability patient was progression-free at Day 78, calculated as total patients receiving treatment and with an overall response of stable disease (SD), partial response (PR), or complete response (CR) at Week 12, divided by total patients. For those alive and not progressed at or before Week 12, PFS censored on date of last evaluable tumor assessment (TA) at or before Week 12. Those with an assessment of PD prior to Week 12 and subsequent assessment of SD, PR, or CR at Week 12 were called progression-free at Week 12. Those with no recorded postbaseline TA dated on or before Day 109, and who had not died on or before Day 109, were censored at randomization. PD=at least 25% increase in sum of products of all index lesions or appearance of any new lesions. Both an investigator and independent review committee (IRC) assessed radiologic imaging studies, photographs of skin lesions, and clinical data. IRC assessment was considered primary over that of the investigators.
Duration of Stable Disease (SD): Randomized Participants With Stable Disease Week 12 to date of disease progression or death up to data cutoff for primary endpoint (approximately 5 years) Duration of SD was defined in those whose Best Overall Response (BOR) was SD, per independent review committee (IRC) as the time between Week 12 and date of progressive disease (PD) or death , whichever occurs first. For those who underwent tumor resection following Week 12 but prior to PD, duration of SD was censored on date of last evaluable tumor assessment (TA) prior to resection. For those with BOR of SD at Week 12, date of PD was used in analysis of duration of SD. For those with BOR=SD who have not subsequently progressed and who remain alive, duration of SD censored on date of last evaluable TA. Modified criteria of the World Health Organization (mWHO): SD=insufficient decrease to qualify for partial response or sufficient increase to qualify for PD; PD=an increase of 25% or more in sum of products of longest diameter and greatest perpendicular diameter of index lesions compared with smallest recorded sum, or appearance of 1 or more new lesions.
Best Overall Response Rate (BORR) First dose to last tumor assessment at data cutoff for primary endpoint (approximately 5 years) BORR=number with Best Overall Response (BOR) of complete response (CR) or partial response (PR), divided by total number of randomized patients. BOR=date of first dose to the last tumor assessment prior to subsequent cancer therapy (including tumor resection surgery but excluding palliative local radiotherapy for bone lesions). Independent review committee assessment. Modified criteria of the World Health Organization (mWHO): CR=disappearance of all lesions; no evidence of progressive disease; PR=50% or greater decrease in the sum of products of the longest diameter and greatest perpendicular diameter of all index lesions compared with baseline. Immune-related (ir) response criteria (irRC) assess tumor response in patients on immunotherapy: irCR=disappearance of all lesions in 2 consecutive observations at least 4 weeks apart; irPR=50% or greater decrease in total measureable tumor burden compared with peak in 2 observations at least 4 weeks apart.
Duration of Response (DOR): Randomized Participants With Response of Complete Response (CR) or Partial Response (PR) Day of CR or PR to day of PD or death up to data cutoff for primary endpoint (approximately 5 years) DOR defined in those with Best Overall Response (BOR)=CR or PR per independent review committee (IRC) as time between date of response of confirmed CR or PR, whichever occurred first, and date of PD or death. If PR assessed before CR, DOR confirmed at earlier time-point showing PR. Modified criteria of the World Health Organization (mWHO): CR=disappearance of all lesions;no evidence of PD; PR=50% or greater decrease in the sum of products of longest and greatest perpendicular diameters (SPD) of all index lesions compared with baseline. PD=an increase of 25% or greater in SPD of index lesions compared with the smallest recorded sum, or appearance of 1 or more new lesions. Immune-related response criteria (irRC): SD=50% decrease in total measurable tumor burden compared with peak cannot be established nor 25% increase compared with nadir, in absence of unequivocal progression of nonindex lesions. Unconfirmed immune-related (ir) CR, irPR, or irPD=irSD.
Percentage of Participants With Brain Metastasis-Free Survival at Time of Data Cutoff Date of randomization up to data cutoff for primary endpoint (approximately 5 years) Brain metastasis-free survival was defined as the time from randomization to the date of progression with a new lesion located in the brain. New brain lesions prior to Week 12 constituted a progression event (unlike main progression-free survival analysis). A participant who dies without documentation of a brain lesion was considered to have progressed with brain metastasis on the date of death. Participants who are free of brain metastasis were censored on the date of their last tumor assessment. An independent review committee evaluated images of participants with clinical symptoms to determine the number of those free of brain metastasis. The brain metastasis-free status was reported as a percent of participants (n/N), where n= participants with metastasis-free brains at data cutoff for the Primary Endpoint and N= randomized participants. A 2-sided Clopper and Pearson confidence interval was performed.
Time to Response: All Randomized Participants With Response to Treatment First dose to date of BOR up to data cutoff for primary endpoint (approximately 5 years) Time to response was defined as the time between the first dose of study therapy and the date when measurement criteria were met for Best Overall Response (BOR) of partial response (PR) or complete response (CR), whichever occurred first, per independent review committee. Note that if an overall response of PR occurred before confirmation of CR, the time to response endpoint was not determined by the time that the BOR of CR was shown but rather by the earlier time point showing PR. Modified criteria of the World Health Organization: CR=disappearance of all lesions; no evidence of progressive disease (PD); PR=50% or more decrease in the sum of products of the longest and greatest perpendicular diameters (SPD) of all index lesions compared with baseline; PD=an increase of 25% or greater in the SPD of index lesions compared with the smallest recorded sum, or the appearance of 1 or more new lesions.
Number of Participants With Adverse Events (AEs), Drug-related AEs, AEs Leading to Discontinuation, Serious Adverse Events (SAEs), Drug-related SAEs, Drug-related Hypersensitivity, Immune-related AEs/SAEs, and Inflammatory AEs/SAEs Week 1 (First Dose) to 70 days after last dose of study up to data cutoff for primary endpoint (approximately 5 years) AE=any new undesirable symptom, sign, clinically significant laboratory abnormality, or medical condition occurring after starting study treatment, even if the event was not considered to be drug-related. SAE=a medical event that at any dose results in death, persistent or significant disability/incapacity, or drug dependency/abuse; is life-threatening, an important medical event, or a congenital anomaly/birth defect; or requires or prolongs hospitalization. Treatment-related=having certain, probable, possible, or missing relationship to study drug. Grade (Gr) 1=Mild, Gr 2=Moderate, Gr 3=Severe, Gr 4= Potentially Life-threatening or disabling. Randomization=Day 1; start of treatment (first dose)=Week 1. Summarization time frame is from first dose to 70 days after last dose of study at time of 414 deaths.
Number of Participants With Grade 2-3 and Grade 3-4 Immune-related Adverse Events (irAEs) With Resolution Resolved Week 1 (first dose) to 70 days after last dose up to data cutoff for primary endpoint (approximately 5 years) irAEs included the categories: gastrointestinal (GI), diarrhea, liver, endocrine, and skin. Grade 2=moderate adverse events (AEs); minimal, local, or noninvasive intervention indicated. Grade 3=severe AEs, medically significant but not immediately life-threatening. Grade 4=life-threatening consequences; urgent intervention indicated. Resolution is defined as improvement to Grade 1 or less or to the Grade at baseline (prior to treatment).
Time to Resolution of Grade 2-3, Grade 3-4 Immune-related Adverse Events (irAEs) Week 1 (first dose) to 70 days after last dose up to database lock for primary endpoint (approximately 5 years) irAEs included the categories: gastrointestinal (GI), diarrhea, liver, endocrine, and skin. Grade 2=Moderate adverse events (AEs); minimal, local or noninvasive intervention indicated. Grade 3=severe AEs, medically significant but not immediately life-threatening. Grade 4=life-threatening consequences; urgent intervention indicated. Time to resolution is defined as improvement to Grade 1 or less or to the Grade at baseline (prior to treatment).
Trial Locations
- Locations (33)
Thompson Cancer Survival Center
🇺🇸Knoxville, Tennessee, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
St Joseph Oncology Inc
🇺🇸Saint Joseph, Missouri, United States
University Of New Mexico Cancer Center
🇺🇸Albuquerque, New Mexico, United States
Ellis Fischel Cancer Center
🇺🇸Columbia, Missouri, United States
Joe Arrington Cancer Research And Treatment Center
🇺🇸Lubbock, Texas, United States
Local Institution
🇬🇧Guildford, Surrey, United Kingdom
Lowcountry Hematology & Oncology, Pa
🇺🇸Mount Pleasant, South Carolina, United States
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
Hutchinson Clinic, Pa
🇺🇸Hutchinson, Kansas, United States
Dana Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Pacific Cancer Medical Center
🇺🇸Anaheim, California, United States
Wilshire Oncology Medical Group Inc
🇺🇸La Verne, California, United States
Comprehensive Cancer Center
🇺🇸Palm Springs, California, United States
The Angeles Clinic And Research Institute
🇺🇸Los Angeles, California, United States
Saint Francis Hospital And Medical Center
🇺🇸Hartford, Connecticut, United States
Hematology Oncology, P.C.
🇺🇸Stamford, Connecticut, United States
Orlando Health, Inc. M.D. Anderson Cancer Center Orlando
🇺🇸Orlando, Florida, United States
Cancer Specialists Of North Florida Beaches
🇺🇸Jacksonville, Florida, United States
University Of Chicago
🇺🇸Chicago, Illinois, United States
Hematology Oncology Associates Of The Treasure Coast
🇺🇸Port Saint Lucie, Florida, United States
Mid-Illinois Hematology/Oncology Associates, Ltd.
🇺🇸Normal, Illinois, United States
Oncology Specialists, Sc
🇺🇸Park Ridge, Illinois, United States
Central Indiana Cancer Centers
🇺🇸Fishers, Indiana, United States
Kentucky Cancer Clinic
🇺🇸Hazard, Kentucky, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Sinai Hospital Of Baltimore
🇺🇸Baltimore, Maryland, United States
St. Luke'S Hospital & Health Network
🇺🇸Bethlehem, Pennsylvania, United States
Blumenthal Cancer Center
🇺🇸Charlotte, North Carolina, United States
Virginia Cancer Institute
🇺🇸Richmond, Virginia, United States
Sharp Clinical Oncology Research
🇺🇸San Diego, California, United States
Vanderbilt-Ingram Cancer Ctr
🇺🇸Nashville, Tennessee, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States