Acute Renal Salt Handling in Orthostatic Intolerance
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Urinary Na excretion
研究概览
简要总结
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.
详细描述
Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject)
排除标准
- •Overt or acute cause for orthostatic tachycardia
- •Hypertension (BP>145/95 or need for anti-hypertensive medications)
- •QRS duration > 120 msec on EKG
- •Pregnancy
结局指标
主要结局
Urinary Na excretion
时间窗: 24h and then hourly post saline load
次要结局
- Catecholamine levels(1 day)
研究者
Satish R. Raj
Assistant Professor of Medicine & Pharmacology
Vanderbilt University