Acute Renal Salt Handling in Orthostatic Intolerance
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Vanderbilt University
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Urinary Na excretion
Study Overview
Brief Summary
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.
Detailed Description
Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject)
Exclusion Criteria
- •Overt or acute cause for orthostatic tachycardia
- •Hypertension (BP>145/95 or need for anti-hypertensive medications)
- •QRS duration > 120 msec on EKG
- •Pregnancy
Outcomes
Primary Outcomes
Urinary Na excretion
Time Frame: 24h and then hourly post saline load
Secondary Outcomes
- Catecholamine levels(1 day)
Investigators
Satish R. Raj
Assistant Professor of Medicine & Pharmacology
Vanderbilt University