跳至主要内容
临床试验/NCT00581633
NCT00581633进行中(未招募)不适用

Acute Renal Salt Handling in Orthostatic Intolerance

Vanderbilt University2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2007年2月1日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
30
试验地点
2
主要终点
Urinary Na excretion

研究概览

简要总结

The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.

详细描述

Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject)

排除标准

  • Overt or acute cause for orthostatic tachycardia
  • Hypertension (BP>145/95 or need for anti-hypertensive medications)
  • QRS duration > 120 msec on EKG
  • Pregnancy

结局指标

主要结局

Urinary Na excretion

时间窗: 24h and then hourly post saline load

次要结局

  • Catecholamine levels(1 day)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Satish R. Raj

Assistant Professor of Medicine & Pharmacology

Vanderbilt University

研究点 (2)

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