Improving recovery after liver transplantation by controlling the blood supply to the transplanted liver
Phase 3
- Conditions
- Health Condition 1: null- Adult patients with end stage liver disease undergoing living donor liver transplantationHealth Condition 2: K74- Fibrosis and cirrhosis of liver
- Registration Number
- CTRI/2017/09/009659
- Lead Sponsor
- Mettu Srinivas Reddy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
First liver only transplant
Exclusion Criteria
1. Paediatric transplants
2. Super-urgent liver transplants
3. Liver-kidney transplants
4. Patients needing complex portal or arterial flow reconstruction
5. Patients with portal pressure >15mmHg or <6mmHg
Patients with severe atherosclerosis around the coeliac axis
Patients unable to give informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite complication rate (Early allograft dysfunction or greater than Clavien 3A morbidity)Timepoint: at 30 days after liver transplant
- Secondary Outcome Measures
Name Time Method 1. Intra-op portal haemodynamics <br/ ><br>2. Postoperative liver function tests, <br/ ><br>3. Serum amylase <br/ ><br>4. Plaletet counts <br/ ><br>5. Need for platelet transfusion <br/ ><br>6. Ascitic drain output <br/ ><br>7. Development of small for size syndrome <br/ ><br>8. Duration of ITU stay <br/ ><br>9. Hospital stay <br/ ><br>10. Any morbidity related to splenic artery ligation <br/ ><br> <br/ ><br>Timepoint: Intra-operative and post-operative period upto three months