ISRCTN91938977已完成未知
Investigating Non-response to Cardiac Resynchronisation: Evaluation of Methods to Eliminate Non-response and Target Appropriate Lead location in patients with Coronary Artery Disease
niversity of Calgary (Canada)0 个研究点目标入组 300 人开始时间: 2008年6月17日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Left ventricular ejection fraction (LVEF) less than or equal to 0.35 measured within three months of enrolment
- •2. Specific Activity Scale (SAS) class 3 or 4 symptoms (moderate to severe functional capacity limitation due to heart failure) within 1 month of enrolment
- •3. QRS width greater than 120 ms
- •4. Confirmed dyssynchrony on screening echo
- •5. Documented history of ischaemic heart disease (prior myocardial infarction, prior coronary artery bypass, prior coronary angioplasty, or imaging confirmation [angiogram, cardiac MRI])
- •6. On stable doses of angiotensin converting enzyme (ACE) inhibitor or angiotensin II blocker and a beta-blocker for greater than or equal to two months unless medically contra-indicated
- •7. Controlled heart rate if in permanent atrial fibrillation (AF) (resting rate less than 70 and maximal rate less than 120 bpm)
- •8. Patients aged 18 years or older
排除标准
- •1. Unable or unwilling to provide informed consent
- •2. Medical condition other than heart failure likely to cause death within 12 months
- •3. Cardiac transplant planned within six months
- •4. Known contra-indication to transvenous CRT device implant (e.g., active sepsis, artificial tricuspid valve, known vascular occlusion that will prevent delivery of transvenous leads)
- •5. Clinically significant myocardial infarction within last two months
- •6. Coronary artery bypass graft surgery less than or equal to two months or coronary angioplasty less than or equal to one month
研究者
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