Chronic Total Occlusion Registry

Terminated

• Conditions: Coronary Stenosis; Coronary Occlusion; Coronary Artery Stenosis
• Interventions: Procedure: Percutaneous coronary intervention; Procedure: Coronary Artery Bypass Grafting; Drug: Medical treatment

• Registration Number: NCT04041921
• Lead Sponsor: Seung-Jung Park

Brief Summary

This study evaluated the long-term outcome of patients with chronic total occlusion treated with percutaneous coronary intervention, medical treatment or coronary artery bypass grafting.

Detailed Description

This study is connected with Decision-CTO trial(NCT01078051). Randomized subjects and registry group subjects from Decision-CTO trial continue 10 years follow-up on this study.

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2019-07-25
• Study First Submitted QC: 2019-07-31
• Study First Posted: 2019-08-01
• Status Verified: 2022-04
• Primary Completion: 2022-04-08
• Study Completion: 2022-04-08
• Last Update Submitted: 2022-04-11
• Last Update Posted: 2022-04-18

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 4006

Inclusion Criteria

• Patients with angina or silent ischemia and documented ischemia
• Patients with De novo chronic coronary occlusion ≥ 3months and reference diameter ≥ 2.5 mm on coronary angiography
• Age > 18 years

Exclusion Criteria

• Refuse to participate in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Chronic coronary occlusion patients	Percutaneous coronary intervention	≥3 months chronic total occlusion on coronary angiography
Chronic coronary occlusion patients	Coronary Artery Bypass Grafting	≥3 months chronic total occlusion on coronary angiography
Chronic coronary occlusion patients	Medical treatment	≥3 months chronic total occlusion on coronary angiography

Primary Outcome Measures

Name	Time	Method
Composite event of all cause death, myocardial infarction, stroke or all kinds of repeat revascularization	10 years

Secondary Outcome Measures

Name	Time	Method
Event rate of all cause death	10 years
Event rate of rehospitalization due to acute coronary syndrome	10 years
Event rate of acute myocardial infarction	10 years
Event rate of stroke	10 years
Event rate of Procedural success	5 days	Procedural success is defined as \< 30% final stenosis and the absence of in-hospital event including death, Q-wave myocardial infarction or urgent repeat revascularization.
Event rate of repeat revascularization	10 years
The rate change of left ventricular ejection fraction	10 years
Composite event of death, myocardial, stroke or repeat revascularization	10 years

Trial Locations

Locations (19)

The Catholic University of Korea, Daejeon ST. Mary's Hospital; 🇰🇷 Daejeon, Korea, Republic of

Soon Chun Hyang University Hospital Cheonan; 🇰🇷 Cheonan, Korea, Republic of

Asan Medical Hospital; 🇰🇷 Seoul, Korea, Republic of

SAM hospital; 🇰🇷 Anyang, Korea, Republic of

Chonnam National University Hospital; 🇰🇷 Gwangju, Korea, Republic of

Soon Chun Hyang University Hospital Bucheon; 🇰🇷 Bucheon, Korea, Republic of

Chungbuk National University Hospital; 🇰🇷 Cheongju, Korea, Republic of

Gangwon National Univ. Hospital; 🇰🇷 Chuncheon, Korea, Republic of

Dong-A Medical Center; 🇰🇷 Pusan, Korea, Republic of

Gangneung Asan Hospital; 🇰🇷 Gangneung, Korea, Republic of

Bundang CHA Hospital; 🇰🇷 Seongnam, Korea, Republic of

ChonBuk National University Hospital; 🇰🇷 Jeonju, Korea, Republic of

Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of

The Catholic University of Korea Seoul St. Mary's Hospital; 🇰🇷 Seoul, Korea, Republic of

Wonju Severance Christian Hospital; 🇰🇷 Wonju, Korea, Republic of

Ulsan University Hospital; 🇰🇷 Ulsan, Korea, Republic of

Keimyung University Dongsan Medical Center; 🇰🇷 Daegu, Korea, Republic of

Chungnam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of

Pusan National University Yangsan Hospital; 🇰🇷 Pusan, Korea, Republic of