NCT02753907已完成3 期
Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Change in Lp-PLA2 activity (nmol/mL/min)
研究概览
简要总结
Self-reported healthy participants (n=150) aged 30-65 years with 18.5 kg/m^2 ≤ BMI < 30 kg/m^2 were randomly assigned into three groups: a low linoleic acid (LA, 18:2n-6) group (n=50) replaced 10 mL soy oil with one apple; a medium LA group (control group, n=50) maintained usual food intake; a high LA group (n=50) reduced 1/3 cup of cooked refined rice and consumed 9.9g of soy oil capsules daily as a supplement. Plasma fatty acids and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were measured at baseline and 8 week alongside other cardiovascular disease risk factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 30 to 65 years at beginning of study
- •Subjects with BMI 18.5 to 30 kg/m^2
排除标准
- •Use of any medication or supplements that alter lipid metabolism.
- •Presence of dyslipidemia, diabetes mellitus, hypertension, liver disease, renal disease, chronic disease of the gastrointestinal tract, cerebrovascular disease, pancreatitis or cancer.
- •Women who pregnant or lactating.
- •Drug or alcohol abuse.
结局指标
主要结局
Change in Lp-PLA2 activity (nmol/mL/min)
时间窗: At baseline and end of each 8-week diet period
次要结局
- Change in LDL cholesterol (mg/dL)(At baseline and end of each 8-week diet period)
- Change in HDL cholesterol (mg/dL)(At baseline and end of each 8-week diet period)
- Change in triglyceride (mg/dL)(At baseline and end of each 8-week diet period)
- Change in total cholesterol (mg/dL)(At baseline and end of each 8-week diet period)
研究者
研究点 (2)
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