Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer
Not Applicable
Completed
- Conditions
- Colorectal Surgery
- Interventions
- Drug: fentanyl-based analgesiaDrug: local anesthetic wound infiltration-based anlagesia
- Registration Number
- NCT02012244
- Lead Sponsor
- Severance Hospital
- Brief Summary
The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- ASA class I-III
- 20-80 years old
- elective laparoscopic colorectal surgery for cancer
Exclusion Criteria
- drug allergy
- significant renal or hepatic impairment
- sign of infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description fentanyl-based analgesia fentanyl-based analgesia fentanyl intravenous patient-controlled analgesia + additional pethidine local anesthetic wound infiltration-based anlagesia local anesthetic wound infiltration-based anlagesia continuous wound inflitration with ropivacaine + tramadol intravenous patient-controlled analgesia + additional ketorolac or propacetamol
- Primary Outcome Measures
Name Time Method NK cell activity 48 hours NK cell activity : preoperation, POD 1, POD 2
IL-2 48 hours IL-2 level : preoperation, POD 1, POD 2
- Secondary Outcome Measures
Name Time Method Complication and recurrence 1 year Postoperative complication, recurrence
Trial Locations
- Locations (1)
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine
🇰🇷Sedoul, Korea, Republic of