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Clinical Trials/NCT07262892
NCT07262892
Recruiting
Not Applicable

Three-Dimensional Evaluation of the Effects of Different Maxillary Expansion Methods

Büşra Zeynep Yörük1 site in 1 country60 target enrollmentStarted: November 20, 2025Last updated:

Overview

Phase
Not Applicable
Status
Recruiting
Sponsor
Büşra Zeynep Yörük
Enrollment
60
Locations
1
Primary Endpoint
Change in Maxillary First Molar Tipping

Overview

Brief Summary

This controlled prospective clinical trial aims to evaluate the effectiveness of different maxillary expansion methods in children with maxillary transverse deficiency. A total of 60 participants will be included: 20 patients will receive Invisalign Palatal Expander (IPE), 20 will receive acrylic cap splint Rapid Maxillary Expansion (RME), and 20 will serve as an untreated control group. Three-dimensional (3D) intraoral and extraoral scans will be taken at the end of expansion, at 3 months, and at 6 months. Primary outcomes include maxillary arch width, first molar angulation, palatal surface area, and palatal volume. Secondary outcomes include soft tissue changes in the facial region. This study provides a direct comparison between a traditional and a modern digital expansion method, generating evidence for clinical decision-making in pediatric orthodontics.

Detailed Description

Maxillary transverse deficiency is a common craniofacial problem that often presents with posterior crossbite and dental crowding. Rapid Maxillary Expansion (RME) achieves sutural separation and bone remodeling, typically activated at 0.5 mm per day. Invisalign® Palatal Expander (IPE) is a modern digital system using 3D printing to produce removable nylon expanders adapted to palatal curvature, with 0.25 mm activations, simplifying oral hygiene and eliminating screw activation.

This controlled prospective clinical trial will recruit 60 children with maxillary transverse deficiency. Participants will be assigned to three groups: IPE (n=20), RME (n=20), and untreated control (n=20). Intraoral scans will be obtained at the end of expansion, at 3 months, and at 6 months to create three-dimensional digital models. Maxillary dental arch widths, first molar angulations, palatal surface areas, and volumes will be measured. Extraoral 3D facial scans will evaluate soft tissue changes, including nasal tip, alar width, and interzygomatic distance.

Statistical analyses will be performed using SPSS, applying t-tests for intra- and inter-group comparisons. The study aims to provide comparative data on a traditional (RME) and a contemporary digital (IPE) maxillary expansion method. No prior studies have directly compared these two techniques in children.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
6 Years to 12 Years (Child)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Children aged 6-12 years
  • Good oral hygiene and adequate patient cooperation
  • No previous orthodontic expansion treatment

Exclusion Criteria

  • Systemic diseases affecting growth, bone metabolism, or craniofacial development
  • Craniofacial syndromes or congenital anomalies
  • Severe behavioral or cooperation problems
  • Previous orthodontic or orthopedic maxillary expansion
  • Patients undergoing medications that affect bone metabolism

Outcomes

Primary Outcomes

Change in Maxillary First Molar Tipping

Time Frame: Baseline (T0), 3 months after expansion (T1), and 6-month retention period (T2)

The angulation of the maxillary first molars will be measured using three-dimensional digital models obtained at T0, at 3 months after completion of expansion (T1), and at the 6-month retention follow-up (T2). Angular changes will be calculated through superimposition of maxillary 3D models and standardized angular measurements.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Büşra Zeynep Yörük
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Büşra Zeynep Yörük

Phd Student

Bezmialem Vakif University

Study Sites (1)

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