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临床试验/NCT04160780
NCT04160780已完成不适用

Lateral Sinus Augmentation Using L-PRF and Xenograft: Radiographic and Histomorphometry Analysis.

British University In Egypt0 个研究点目标入组 18 人开始时间: 2016年3月26日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
18
主要终点
histomorphometric analysis

研究概览

简要总结

Severe maxillary atrophy occurs after extraction of teeth in poster maxilla due to dimensional changes occur after removal; besides, sinus membrane pneumatization causes alveolar bone resorption, different classification for remaining alveolar bone in the posterior maxilla were done. In this study, the ABC sinus classification was followed in case selection. A sinus augmentation is done with several techniques. Sinus membrane elevation is done with two different approaches, either the crestal approach or lateral window approach.

Using biofiller material for sinus membrane elevation has been tried by many researchers, using a bone graft, platelet concentrates preparation, collagen membranes, tenting screws, or with implant tenting.

In this study, sinus augmentation was performed using a lateral window approach using L-PRF as sole biofiller material in one group, xenograft as only biofiller material in the second group and mixed xenograft with L-PRF in the third group. Histomorphometric analysis was done from the core biopsy after three months of augmentation, and implant placement was done.

After three months, prosthetic parts were placed. The results of this study show that the augmentation of the sinus using L-PRF mixed with bone graft is showing the best results followed by L-PRF only, and the least was xenograft.

From this point of discussion, it can be considered that using L-PRF as sole biofiller material in sinus augmentation.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
20 Years 至 45 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy adult patients.
  • Both sex, males and females.
  • Age from 24 - 49 years old.
  • All patients were free from any systemic diseases as evidenced by Burkett's oral medicine health history questionnaire.
  • Extraction done at posterior maxilla involved with the maxillary sinus.
  • Remaining alveolar bone ≤ 5mm vertically and ≥ 4mm horizontally and from 1.5 mm to 3.5 mm vertically.
  • Gingival biotype 1-2mm thickness.
  • Patient has no previous surgery in Maxillary antrum.

排除标准

  • Pregnant and breast-feeding females.
  • Mentally retarded Patients.
  • Presence of hematologic disease.
  • Previous radiation, chemotherapy, or immunosuppressive treatments.
  • Diabetes mellitus, metabolic bone disease, ongoing treatment with bisphosphonates drugs, or pregnancy.
  • Patient with history of chronic sinus pathosis
  • Anticoagulant drugs, Endocarditis risk factors, renal and hepatic failure.

结局指标

主要结局

histomorphometric analysis

时间窗: 3 months

After three months from sinus augmentation, a second surgery will be done for implant placement; during this procedure, a bone core biopsy will be harvested. The biopsy will be stained with mason stain for histomorphometric analysis. The aim is to measure the newly formed bone for three months.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Alhassan Diab

assistant lecturer

British University In Egypt

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