Volume of Perirenal Fat and Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Numbers of renal interstitial fibrosis
研究概览
简要总结
The perirenal fat may alter renal function by secreting fibrotic inflammatory agents when accumulates during obesity. Nephrectomy for renal tumor is a model that would provide tissue samples to test this hypothesis. Renal tumor could itself be responsible for inflammation and fibrosis in its environment. This study aims to measure the influence of the tumor on his kidney Environment and fat and define molecular markers not influenced by renal tumor. The main objective is to compare the inflammation of the perirenal fat taken in two locations in the same patient, in contact and 4 cm from the outer edge of the tumor, each patient as his own control. The secondary objective is to compare the degree of interstitial fibrosis of the renal cortex in the same sampling methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or more
- •Indication nephrectomy for kidney tumor
- •Stadium T1a, T1b or T2 and M0 according to the TNM (Tumor Nodes Metastasis) classification of tumors
排除标准
- •Nephrectomy indication for chronic pyelonephritis
- •Asian topic because of the difference threshold values used to characterize the metabolic syndrome in this population
- •Diabetes type I or II due to a high score of renal interstitial fibrosis
- •Infection with HIV (Human immunodeficiency virus)
- •Partial nephrectomy (a part of the kidney on the side of the tumor is left in place)
结局指标
主要结局
Numbers of renal interstitial fibrosis
时间窗: 1 day
次要结局
未报告次要终点