Comparison The Postoperative Effects of Local and Systemic Antibiotics Applied With Platelets Rich Fibrin

Completed

• Conditions: Impacted Wisdom Tooth
• Interventions: Diagnostic Test: Diagnosis; Procedure: traditional osteotomies; Biological: Platelet Rich Fibrin; Drug: Antibiotics, Penicillin; Drug: Analgesic; Drug: Antibiotic

• Registration Number: NCT04989127
• Lead Sponsor: Ceren Melahat Donmezer

Brief Summary

The aim of this study was investigate the comparison of postoperative effects of local antibiotics mixed with platelet-rich fibrin and postoperative systemic antibiotic applications prescribed for mandibular impacted third molar tooth extraction. The study included a total of 75 patients with impacted mandibular third molar. Patients were evaluated in 5 randomly separated groups. For the first and third group, Platelets Rich Fibrin+ systemic Antibiotics were applied into the tooth socket and for the second and fourth group, Platelets Rich Fibrin + local antibiotics were applied, respectively. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-17
• Primary Completion: 2021-02-20
• Study Completion: 2021-02-21
• Study First Submitted: 2021-07-01
• Study First Submitted QC: 2021-07-24
• Study First Posted: 2021-08-04
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-21
• Last Update Posted: 2024-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• The patient had no systemic diseases, no taken opioids for a long period, no current infections or acute pericoronitis, no smoke or drink alcohol, no pregnancy, the absence of allergy to penicillin and presence of penicillin allergy.

Exclusion Criteria

• pericoronitis, no inflammation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control group	traditional osteotomies	platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed.
group 1	Diagnosis	platelet-rich fibrin placed into the socket of the extracted tooth.+ Augmentin 1 gr tablet prescribed 3 times a day
group 1	traditional osteotomies	platelet-rich fibrin placed into the socket of the extracted tooth.+ Augmentin 1 gr tablet prescribed 3 times a day
group 1	Platelet Rich Fibrin	platelet-rich fibrin placed into the socket of the extracted tooth.+ Augmentin 1 gr tablet prescribed 3 times a day
group 1	Antibiotics, Penicillin	platelet-rich fibrin placed into the socket of the extracted tooth.+ Augmentin 1 gr tablet prescribed 3 times a day
group 1	Analgesic	platelet-rich fibrin placed into the socket of the extracted tooth.+ Augmentin 1 gr tablet prescribed 3 times a day
group 2	Diagnosis	platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.
group 2	traditional osteotomies	platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.
group 2	Platelet Rich Fibrin	platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.
group 2	Antibiotics, Penicillin	platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.
group 2	Analgesic	platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.
group 3	Diagnosis	platelet-rich fibrin placed into the socket of extracted tooth + Clin 150 mg capsule prescribed 4 times a day
group 3	traditional osteotomies	platelet-rich fibrin placed into the socket of extracted tooth + Clin 150 mg capsule prescribed 4 times a day
group 3	Platelet Rich Fibrin	platelet-rich fibrin placed into the socket of extracted tooth + Clin 150 mg capsule prescribed 4 times a day
group 3	Analgesic	platelet-rich fibrin placed into the socket of extracted tooth + Clin 150 mg capsule prescribed 4 times a day
group 4	Diagnosis	platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.
group 4	traditional osteotomies	platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.
group 4	Platelet Rich Fibrin	platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.
group 4	Analgesic	platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.
control group	Diagnosis	platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed.
control group	Platelet Rich Fibrin	platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed.
control group	Analgesic	platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed.
group 3	Antibiotic	platelet-rich fibrin placed into the socket of extracted tooth + Clin 150 mg capsule prescribed 4 times a day
group 4	Antibiotic	platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.

Primary Outcome Measures

Name	Time	Method
visual analogue scale (VAS)	day 15	It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.
Trismus	day 15	Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.
swelling	day 15	measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

Trial Locations

Locations (1)

Near east University; 🇨🇾 Nicosia, Lefkosa, Cyprus