Personalisation of anti-obesity medication selection based on Eating Behaviour Traits: examining the effect of the novel Auckland Eating Behaviour Questionnaire on weight loss in patients with obesity and type 2 diabetes

Auckland District Health Board0 个研究点目标入组 175 人开始时间: 2022年5月16日最近更新: 2022年5月23日

适应症

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•Participants, 18 - 75 years of age, male and female, who have obesity, WHO class 1 and above (BMI 30- 50 kg/m2) will be invited to take part. Participants will need to be willing and able to give informed consent for participation in the study and benefit from weight loss. Only those with one dominant eating behaviour (EB) domain score of >2 Standard deviations of the mean will be eligible to take part.
•People in the lifestyle only group will have eating behaviours that match all possible eating behaviour traits. Patients with type 2 diabetes can be on oral hypoglycaemic medications, including metformin, sulphonylurea, pioglitazone, an SGLT2 inhibitor. Participants can have stable obesity-related complications.

•Previous bariatric surgery, being diagnosed or currently suffering from a mental health problem, being prescribed psychotropic medication that could interfere or are a contraindication for the use of any one of the three weight loss medications. Other exclusion criteria include the presence of eating disorders (previously diagnosed or currently assessed) Patients with type 1 diabetes will be excluded, and treatment with a weight loss medication or a GLP1 agonist is an exclusion criterion. Patients cannot be on insulin. Exclusions are complications that would prevent the use of weight management medication, such as recent cardiovascular events, unstable angina, coronary artery bypass grafting, ischaemic stroke, myocardial infarction, percutaneous coronary intervention, epilepsy, or psychiatric disorder.

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