Concentrations of Salmeterol in Blood and Urine
- Registration Number
- NCT00914901
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
The purpose of the study is to assess the blood and urine concentrations of inhaled salmeterol.
- Detailed Description
The purpose of the study is to assess the serum and urine concentrations of salmeterol after inhalation of 100 microgram salmeterol in one dose.
Furthermore, to evaluate any difference in three groups: 10 healthy men, 10 male asthmatic subjects and 10 male elite athletes with asthma.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 30
Inclusion Criteria
- Physician-diagnosed asthma with positive reversibility or challenge test.
- Informed consent.
- Age between 18-45 years.
- Sex: male.
- Asthma classified as mild to moderate according to GINA guidelines.
- Used beta-2-agonist in minimum 12 months.
Exclusion Criteria
- Smokers or ex-smokers with a smoking history of 10 pack years or more.
- Respiratory tract infections within the last 2 weeks prior to study day.
- Subjects with other chronic diseases than asthma and/or allergy.
- Allergy towards the study medicine.
- Use of beta-2-agonist 10 days prior to study day.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Healthy inhaled salmeterol 10 healthy men Asthmatics inhaled salmeterol 10 male asthmatic subjects Elite athletes with asthma inhaled salmeterol 10 male elite athletes with asthma
- Primary Outcome Measures
Name Time Method Serum and urine concentrations of salmeterol baseline, 4, 8, and 12 hours after medicine administration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bispebjerg Hospital, Respiratory Research Unit
🇩🇰Kobenhavn NV, Denmark