Determination of reference values: numbers, repertoire and products of leukocytes in immunological healthy elderly

• Conditions: reference values; 10024324; 10027665; 10002252

• Registration Number: NL-OMON50827
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

- Immunological healthy elderly (without immunological history)
- No use of immunosuppressive drugs
- Age >50 years
- Signed informed consent

Exclusion Criteria

- medical immunological history
- diagnosis of diabetes, cardiovascular disease, leukemia/lymphoma,
malignancies, systemic auto-immune diseases/rheumatoid disease
- use of immunosuppressive drugs
- no signed informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Insight in age-dependent distribution of leukocytes (subtypes), their IG/TR<br /><br>repertoire and their production of antibodies and cytokines.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Use of results for correct (and age-dependent) interpretation of abnormal<br /><br>values **in certain patient groups (such as e.g. patients with chronic<br /><br>lymphocytic leukemia, autoimmune diseases, etc.).</p><br>