Ferroptosis Role in the Pathophysiology of Systemic Lupus Erythematosus
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Measurement of lipid peroxidation in regulatory T lymphocytes population in lupus subjects.
研究概览
简要总结
The study aims at defining the role of ferroptosis s in the physiopathology of systemic lupus erythematosus (SLE). Ferroptosis (phenomenon of cellular death regulated by iron) is a metabolic pathway potentially implicated in SLE with potential for the discovery of new therapeutic strategies.
详细描述
Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting various organs. Regulatory T cells (Treg) and platelets play a crucial role in the pathogenesis of SLE by regulating immunity and promoting inflammation. Ferroptosis, an iron-regulated cell death process, is emerging as a key player in many diseases, including SLE.
The project, FERROLUP, aims to understand the role of ferroptosis in SLE and to explore the therapeutic potential of selenium compounds to modulate this process. Recent work has identified down-regulation of glutathione peroxidase 4 (GPx4) by immune complexes and interferon-alpha in neutrophils, leading to ferroptosis and worsening of SLE. In addition, data suggest the involvement of ferroptosis in lupus nephritis.
The Bordeaux team has developed selenium compounds, GPx4 mimics, capable of inhibiting ferroptosis in lupus neutrophils. These compounds have shown promising efficacy in mouse models and preliminary human studies in another inflammatory disease. The FERROLUP project aims to characterize the level of lipid peroxidation and GPx4 expression in SLE patients, and to test the impact of selenium compounds on the inhibition of ferroptosis induced by P-selectin, a molecule involved in Treg dysfunction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 18 years;
- •diagnosis of systemic lupus erythematosus;
- •being affiliated to health insurance, willing to participate and to sign informed consent;
- •control group : patients with a diagnosis of rheumatoid arthritis or an inflammatory bowel disease.
排除标准
- •pregnant or breastfeeding women;
- •patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).
研究组 & 干预措施
Systemic lupus erythematosus (SLE)
干预措施: blood sample (Biological)
Rheumatoid arthritis or an inflammatory bowel
干预措施: blood sample (Biological)
结局指标
主要结局
Measurement of lipid peroxidation in regulatory T lymphocytes population in lupus subjects.
时间窗: At baseline (Day 0)
次要结局
- Measurement of lipid peroxidation in regulatory T lymphocytes population in lupus subjects and controls.(At baseline (Day 0))
- Measurement of lipid peroxidation in other immune cells (T and B lymphocyte populations) in lupus subjects and controls(At baseline (Day 0))
- GPX4 expression in lupus subjects and controls.(At baseline (Day 0))
- Correlation between ferroptosis markers and the level of activity in B lymphocyte populations(At baseline (Day 0))
- In-vitro effect of BXT on different T lymphocytes population in the presence of P-selectin in sera of lupus subjects and controls(At baseline (Day 0))